This study examined the associations between childhood experience and frailty trajectory among middleaged and older Chinese adults. Data were derived from The China Health and Retirement Longitudinal Study. We used data from all of the 4 waves (i.e., 2011, 2013, 2015, 2018) and the life history survey occurred in 2014. A total of 10963 respondents were included. Latent growth curve models were conducted to examine the proposed model. The results showed that adverse childhood experience, childhood socio-economic status, and the objective indicators of childhood health and healthcare were associated with both the baseline level and change rate of frailty trajectory. The perceived childhood health and healthcare conditions were associated with baseline frailty only. Our ndings highlighted the crucial role of childhood antecedents in the progression of frailty at later life. We further provided strong evidence that childhood was an essential life stage for human development. Future social policies and interventions should use childhood experience as a screening tool, as well as promote child protection, health education, and life course interventions.