3-Deoxysappanchalcone isolated from Caesalpinia sinensis shows anticancer effects on HeLa and PC3 cell lines: invasion, migration, cell cycle arrest, and signaling pathway

Lv, Dian; Lai, Qi; Zhang, Qi; Wang, Jihong; Li, Yuan-ce; Zeng, Guang‐Zhi; Yin, Jun-Lin

doi:10.1016/j.heliyon.2022.e11013

Cited by 3 publications

(1 citation statement)

References 48 publications

(52 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Considerable attention has therefore been given to developing NPs strategies to vanquish tumor growth ( Waltenberger, Mocan et al, 2016 ; Tintore, Vidal-Jordana et al, 2019 ). NPs are an important resource for exploring new anti-tumor drugs, which are rich in multi types of active ingredients ( Newman and Cragg, 2016 ), such as polysaccharides ( Chihara, Hamuro et al, 1970 ), flavonoids ( Lv, Lai et al, 2022 ), terpenes ( Zeng, Wang et al, 2018 ), and alkaloids ( Zhang, Qiang et al, 2019 ), which could kill or inhibit cancer cells, and are characterized by multi-target and link effects. As for alkaloids, those with antitumor effects include camptothecin (CPT) ( Chen, Wang et al, 2017 ), matrine ( Ye, Zou et al, 2018 ), vincristine ( Potier, 1989 ), harringtonine ( Jiang, Liu et al, 1983 ), and berberine (BR) ( Goto, Kariya et al, 2012 ), with a wide variety of anti-tumor activities and mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Alkaloid from Alstonia yunnanensis diels root against gastrointestinal cancer: Acetoxytabernosine inhibits apoptosis in hepatocellular carcinoma cells

et al. 2023

Self Cite

View full text Add to dashboard Cite

Liver cancer belongs to Gastrointestinal (GI) malignancies which is a common clinical disease, a thorny public health problem, and one of the major diseases that endanger human health. Molecules from natural products (NPs) or their derivatives play an increasingly important role in various chronic diseases such as GI cancers. The chemical composition of the Alstonia yunnanensis Diels roots was studied using silica column chromatography, gel chromatography, recrystallization, and HPLC, and the compounds were structurally identified by modern spectral analysis using mass spectrometry (MS) and nuclear magnetic resonance (1H-, 13C-, HMQC-, HMBC-, and 1H-1HCOSY-NMR), ultraviolet and visible spectrum (UV), and electronic Circular Dichroism (ECD). Acetoxytabernosine (AC), an indole alkaloid with antitumor activity, was isolated from Alstonia yunnanensis Diels root. The current study aimed to investigate the influence of AC on the cell proliferation of BEL-7402 and SMMC7721 and to elucidate the underlying mechanism. The absolute configuration of AC was calculated by ECD (electronic circular dichroism). The effects of AC on the viability of different tumor cell lines were studied by the SRB method. The death mode of human hepatoma cells caused by AC was studied by TUNEL cell apoptosis detection and AnnexinV-FITC/PI double staining image. Mitochondrial membrane potential was detected by JC-1. The effects of AC on the expression of apoptosis-related proteins (Caspase9, Caspase3, and Parp-1) in SMMC7721 and BEL-7402 cells were detected by western blot. It was found that the absolute configuration of AC is 19(s), 20(s)-Acetoxytabernosine. AC could induce apoptosis of SMMC7721 and BEL-7402, and block the replication of DNA in the G1 phase. Under the treatment of AC, the total protein expression of apoptosis-related proteins (Caspase9, Caspase3, and Parp-1) significantly decreased in SMMC7721 and BEL-7402. The results suggested that AC induced apoptosis through a caspase-dependent intrinsic pathway in SMMC7721 and BEL-7402, and natural product-based drug development is an important direction in antitumor drug discovery and research.

show abstract

Section: Introductionmentioning

confidence: 99%

Alkaloid from Alstonia yunnanensis diels root against gastrointestinal cancer: Acetoxytabernosine inhibits apoptosis in hepatocellular carcinoma cells

et al. 2023

Self Cite

View full text Add to dashboard Cite

show abstract

Improved anti-cancer effects of luteolin@ZIF-8 in cervical and prostate cancer cell lines

Ding,

Chen,

et al. 2024

Heliyon

View full text Add to dashboard Cite

Two new norcassane-type diterpenoids from Mezonevron sinense Hemsl

Chen

et al. 2023

Natural Product Research

View full text Add to dashboard Cite

Two new norcassane-type diterpenoids, named 6β-hydroxy-bisnorcass-13-en-12-one (1) and 6β-hydroxy-bisnorcassan-12-one (2), were isolated from the seeds of Mezonevron sinense Hemsl.. The structures of compounds 1-2 were determined by extensive spectroscopic analysis. Two compounds exhibited immunosuppressive activity with the IC 50 values of 19.35±0.87 μM and 18.69±0.88 μM in the ConA induced T cell model and 65.04±0.83 μM and 48.06±0.76 μM in LPS induced B cell model, respectively.

show abstract

3-Deoxysappanchalcone isolated from Caesalpinia sinensis shows anticancer effects on HeLa and PC3 cell lines: invasion, migration, cell cycle arrest, and signaling pathway

Cited by 3 publications

References 48 publications

Alkaloid from Alstonia yunnanensis diels root against gastrointestinal cancer: Acetoxytabernosine inhibits apoptosis in hepatocellular carcinoma cells

Alkaloid from Alstonia yunnanensis diels root against gastrointestinal cancer: Acetoxytabernosine inhibits apoptosis in hepatocellular carcinoma cells

Improved anti-cancer effects of luteolin@ZIF-8 in cervical and prostate cancer cell lines

Two new norcassane-type diterpenoids from Mezonevron sinense Hemsl

Contact Info

Product

Resources

About