3-Dimensional Elastic Registration System of Prostate Biopsy Location by Real-Time 3-Dimensional Transrectal Ultrasound Guidance With Magnetic Resonance/Transrectal Ultrasound Image Fusion

Abstract

The novel, computer assisted, 3-dimensional transrectal ultrasound biopsy localization system achieved encouraging accuracy with less than 3 mm error for targeting hypoechoic and isoechoic lesions. The ability to register actual biopsy trajectory and perform elastic magnetic resonance/ultrasound image fusion is a significant advantage for future focal therapy application.

Trans-rectal ultrasound visibility of prostate lesions identified by magnetic resonance imaging increases accuracy of image-fusion targeted biopsies

“…However, if mp-MR identifies a highly suspicious prostate lesion, fusion of that stored MR image with the real-time TRUS image may indicate which specific hypo-echoic TRUS lesion best corresponds with the suspected lesion on mp-MR, and should therefore be targeted for TRUS-biopsy. Novel computer-assisted image processing systems may further enhance biopsy accuracy [11][12][13][14].…”

Prostate Cancer Detection Rate with Koelis Fusion Biopsies versus Cognitive Biopsies: A Comparative Study

“…All KG biopsies were performed with Koelis Urostation™ (Koelis, Grenoble, France) and a 3D ultrasound (SonoAceX8, Samsung-Medison) with an endfire transrectal probe. The Urostation™ implements elastic registration for fusing the MRI and 3D ultrasound images, guiding and recording core localization [8]. Targeted biopsies were done on targets, while a variable number of random biopsies were performed depending on the clinical case.…”

“…Fusion imaging can be rigid, with a direct overlay of the mpMRI onto the TRUS images at the time of biopsy, without taking into account the changes in shape and position of the prostate at the time of biopsy, or elastic, with the aim of compensating for prostate deformation at the time of biopsy [7]. Koelis Urostation™ is a device providing elastic fusion imaging, which has shown promising target precision of <3 mm on prostate phantoms [8] and interesting results in terms of CDR [9,10,11,12,13,14,15]. Nevertheless, some authors question its superiority over the cheaper and simpler cognitive technique [16].…”

Fusion Target Biopsy of the Prostate Using Real-Time Ultrasound and MR Images. A Multicenter RCT on Target Biopsy Techniques in the Diagnosis of Prostate Cancer

“…Despite these results MRGB remains controversial due to impracticalities, as its low availability, required expertise and time consuming nature. An upcoming technique is MRI-TRUS fusion (MTF) targeted biopsy [28][29][30][31][32][33][34][35][36][37][38]. MTF devices utilise the high diagnostic yield of the mpMRI for prostate cancer in combination with the practicality and affordability of TRUS biopsy systems by fusing the pre-interventional MR images with real-time ultrasound images.…”