3-Dimensional magnetic resonance imaging of the freely moving human eye

Franceschiello, Benedetta; Sopra, Lorenzo Di; Minier, Astrid; Ionta, Silvio; Zeugin, David; Notter, Michael; Bastiaansen, Jessica; Jorge, João; Yerly, Jérôme; Stuber, Matthias; Murray, Micah M.

doi:10.1016/j.pneurobio.2020.101885

Cited by 10 publications

(5 citation statements)

References 60 publications

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“…Recent free-running concepts using uninterrupted 3D acquisitions enable whole-heart free-breathing MRI where ECG time stamps help resolve cardiac motion retrospectively. 35 Free-running sequences have a fixed scan time, improve ease-of-use, and applications range from anatomical imaging, [36][37][38] to coronary angiography, 39,40 T 1 and T 2 mapping, [41][42][43][44] and flow measurements. 45 Advances in respiratory motion compensation extended with a compressed sensing (CS) reconstruction enabled cardiac-and respiratory-motion-resolved 5D imaging.…”

Section: Introductionmentioning

confidence: 99%

Motion‐resolved fat‐fraction mapping with whole‐heart free‐running multiecho GRE and pilot tone

Mackowiak

Roy

Yerly

et al. 2023

Magnetic Resonance in Med

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Purpose: To develop a free-running 3D radial whole-heart multiecho gradient echo (ME-GRE) framework for cardiac-and respiratory-motion-resolved fat fraction (FF) quantification. Methods: (N TE = 8) readouts optimized for water-fat separation and quantification were integrated within a continuous non-electrocardiogram-triggered free-breathing 3D radial GRE acquisition. Motion resolution was achieved with pilot tone (PT) navigation, and the extracted cardiac and respiratory signals were compared to those obtained with self-gating (SG). After extra-dimensional golden-angle radial sparse parallel-based image reconstruction, FF, R 2 *, and B 0 maps, as well as fat and water images were generated with a maximum-likelihood fitting algorithm. The framework was tested in a fat-water phantom and in 10 healthy volunteers at 1.5 T using N TE = 4 and N TE = 8 echoes. The separated images and maps were compared with a standard free-breathing electrocardiogram (ECG)-triggered acquisition. Results:The method was validated in vivo, and physiological motion was resolved over all collected echoes. Across volunteers, PT provided respiratory and cardiac signals in agreement (r = 0.91 and r = 0.72) with SG of the first echo, and a higher correlation to the ECG (0.1% of missed triggers for PT vs. 5.9% for SG). The framework enabled pericardial fat imaging and quantification throughout the cardiac cycle, revealing a decrease in FF at end-systole by 11.4% ± 3.1% across volunteers (p < 0.0001). Motion-resolved end-diastolic 3D FF maps showed good correlation with ECG-triggered measurements (FF bias of −1.06%). A significant difference in free-running FF measured with N TE = 4 and N TE = 8 was found (p < 0.0001 in sub-cutaneous fat and p < 0.01 in pericardial fat). Conclusion:Free-running fat fraction mapping was validated at 1.5 T, enabling ME-GRE-based fat quantification with N TE = 8 echoes in 6:15 min.

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Section: Introductionmentioning

confidence: 99%

Motion‐resolved fat‐fraction mapping with whole‐heart free‐running multiecho GRE and pilot tone

Mackowiak

Roy

Yerly

et al. 2023

Magnetic Resonance in Med

Self Cite

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“…Dynamic MR eye imaging allows observation of the entire eyeball in full anatomic detail ( Berg et al, 2012 ; Sengupta et al, 2017 ; Franceschiello et al, 2020 ) and can therefore circumvent the aforementioned limitations. Measuring eye movements during blinks, which typically last only 100–300 ms, or saccades (which last only a few dozen milliseconds) requires a spatial and temporal resolution beyond that of classical MRI.…”

Section: Introductionmentioning

confidence: 99%

Real-Time MRI Reveals Unique Insight into the Full Kinematics of Eye Movements

Kirchner

Watson

Lappe

2021

eNeuro

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“…MRI with an in-plane spatial resolution of about 0.5-1.0 mm along each direction can clearly identify eye structures. Importantly, this includes the possibility of imaging the freely moving human eye, which makes fixating or administration of paralytics or anaesthetics obsolete, vastly improving patient comfort and compliance 120 . MRI can readily distinguish between normal anatomy and pathological regions such as the gross tumor volume or retinal detachment.…”

Section: Opportunities For Discoverymentioning

confidence: 99%

Ophthalmic Magnetic Resonance Imaging: Where Are We (Heading To)?

Niendorf

Beenakker²,

Langner

et al. 2021

Current Eye Research

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Magnetic resonance imaging of the eye and orbit (MReye) is a cross-domain research field, combining (bio)physics, (bio)engineering, physiology, data sciences and ophthalmology. A growing number of reports document technical innovations of MReye and promote their application in preclinical research and clinical science. Realizing the progress and promises, this review outlines current trends in MReye. Examples of MReye strategies and their clinical relevance are demonstrated. Frontier applications in ocular oncology, refractive surgery, ocular muscle disorders and orbital inflammation are presented and their implications for explorations into ophthalmic diseases are provided. Substantial progress in anatomically detailed, high-spatial resolution MReye of the eye, orbit and optic nerve is demonstrated. Recent developments in MReye of ocular tumors are explored, and its value for personalized eye models derived from machine learning in the treatment planning of uveal melanoma and evaluation of retinoblastoma is highlighted. The potential of MReye for monitoring drug distribution and for improving treatment management and the assessment of individual responses is discussed. To open a window into the eye and into (patho)physiological processes that in the past have been largely inaccessible, advances in MReye at ultrahigh magnetic field strengths are discussed. A concluding section ventures a glance beyond the horizon and explores future directions of MReye across multiple scales, including in vivo electrolyte mapping of sodium and other nuclei. This review underscores the need for the (bio)medical imaging and ophthalmic communities to expand efforts to find solutions to the remaining unsolved problems and technical obstacles of MReye, with the objective to transfer methodological advancements driven by MR physics into genuine clinical value.

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3-Dimensional magnetic resonance imaging of the freely moving human eye

Cited by 10 publications

References 60 publications

Motion‐resolved fat‐fraction mapping with whole‐heart free‐running multiecho GRE and pilot tone

Motion‐resolved fat‐fraction mapping with whole‐heart free‐running multiecho GRE and pilot tone

Real-Time MRI Reveals Unique Insight into the Full Kinematics of Eye Movements

Ophthalmic Magnetic Resonance Imaging: Where Are We (Heading To)?

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