2010
DOI: 10.1016/j.ejmech.2010.05.065
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3-Formylchromones: Potential antiinflammatory agents

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Cited by 112 publications
(63 citation statements)
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“…While searching for such agents, we focused on chromones, which have been linked with antibacterial, antifungal, and antitumor activities (1). In particular, we focused on 3-formylchromone (3-FC), 3 which has been shown to exhibit antibacterial (2), anti-inflammatory (3), and antitumor (2, 4 -6) activities. How this agent exhibits all these activities is not fully understood, but inhibition of protein-tyrosine phosphatase 1B (7), chelation of bivalent cations (8), multidrug resistance (5), p56 lck tyrosine kinase (9), and thymidine phosphorylase (10) have been implicated.…”
mentioning
confidence: 99%
“…While searching for such agents, we focused on chromones, which have been linked with antibacterial, antifungal, and antitumor activities (1). In particular, we focused on 3-formylchromone (3-FC), 3 which has been shown to exhibit antibacterial (2), anti-inflammatory (3), and antitumor (2, 4 -6) activities. How this agent exhibits all these activities is not fully understood, but inhibition of protein-tyrosine phosphatase 1B (7), chelation of bivalent cations (8), multidrug resistance (5), p56 lck tyrosine kinase (9), and thymidine phosphorylase (10) have been implicated.…”
mentioning
confidence: 99%
“…The Schiff bases prepared from 1 and several arylamines have been evaluated for their antibacterial activities. [42][43][44] The Schiff base 54 has been prepared from 1 and 4-aminoantipyrine by conventional method 45 as well as in an ionic liquid. 46 Many other hetarylamines such as 1,3-diaryl-5-aminopyrazole 55, 47 3-Formylchromones as well as Schiff bases obtainable therefrom can function as ligands towards many metal ions.…”
Section: Methodsmentioning
confidence: 99%
“…1, many Schiff bases are known to be medicinally important and have been found to be promising leads for the design of more efficient antiinflammatory agents. In the past decade, Schiff bases of different heterocycles have displayed remarkable antiinflammatory activity with reduced ulcerogenic effect (Alam et al, 2012;Hunashal et al, 2011;El-Sayed et al, 2011;Khan et al, 2010). Studies also demonstrated that the metal complexes of Schiff bases display enhanced biological activity than their respective free organic compounds (Chohan et al, 1997).…”
Section: Introductionmentioning
confidence: 99%