3-Hydroxymorindone from Knoxia roxburghii (Spreng.) M. A. Rau induces ROS-mediated mitochondrial dysfunction cervical cancer cells apoptosis via inhibition of PI3K/AKT/NF-κB signaling pathway

Chen, Xiao-Jiao; Liu, Zhibo; Li, Xue; Pu, Xue-Mei; Mei, Mi-Jia; Pu, Xin-Ying; Wang, Xin-Ge; Hao, Junjie; Zhang, Fan; Qiu, Bin; Yu, Jie

doi:10.1016/j.jff.2023.105498

Cited by 5 publications

(1 citation statement)

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“…MOMP causes the release of Cytochrome C, which further promotes caspase activation and apoptosis [32][33][34]. Mcl-1, an anti-apoptotic protein, is a member of the Bcl-2 family and is involved in maintaining mitochondrial integrity [35]. Our results showed that the expression levels of Bcl-2, Mcl-1, and Caspase 3 were gradually downregulated in a dosedependent way, while the expression levels of Bax and Cleaved caspase 3 were gradually upregulated after treatment with effusanin B.…”

Section: Discussionmentioning

confidence: 99%

Effusanin B Inhibits Lung Cancer by Prompting Apoptosis and Inhibiting Angiogenesis

Hou,

Li,

Xing

et al. 2023

Molecules

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Cancer is one of the deadliest human diseases, causing high rates of illness and death. Lung cancer has the highest mortality rate among all malignancies worldwide. Effusanin B, a diterpenoid derived from Isodon serra, showed therapeutic potential in treating non-small-cell lung cancer (NSCLC). Further research on the mechanism indicated that effusanin B inhibited the proliferation and migration of A549 cells both in vivo and in vitro. The in vitro activity assay demonstrated that effusanin B exhibited significant anticancer activity. Effusanin B induced apoptosis, promoted cell cycle arrest, increased the production of reactive oxygen species (ROS), and altered the mitochondrial membrane potential (MMP). Based on mechanistic studies, effusanin B was found to inhibit the proliferation and migration of A549 cells by affecting the signal transducer and activator of transcription 3 (STAT3) and focal adhesion kinase (FAK) pathways. Moreover, effusanin B inhibited tumor growth and spread in a zebrafish xenograft model and demonstrated anti-angiogenic effects in a transgenic zebrafish model.

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