3-Imino derivative-sulfahydantoins: Synthesis, in vitro antibacterial and cytotoxic activities and their DNA interactions

Başkan, Ceren; Ertürk, Aliye Gediz; Aydın, Birsen; Sırıken, Belgin

doi:10.1016/j.bioorg.2021.105517

Cited by 5 publications

(2 citation statements)

References 22 publications

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“…However, this detection did not describe the link to the cancer, only that it was detected in the patient, and may in fact have originated from an upper respiratory infection. The third and final paper that was returned described a novel compound that had demonstrated efficacy against both microbes (including Klebsiella ) and MMe cells cultured in vitro ( 40 ). However, no link was made between Klebsiella and MMe.…”

Section: Discussionmentioning

confidence: 99%

Intratumor microbiota as a novel potential prognostic indicator in mesothelioma

Pentimalli¹,

Krstic‐Demonacos²,

Costa³

et al. 2023

Front. Immunol.

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IntroductionDespite increased attention on immunotherapy, primarily immune checkpoint blockade, as a therapeutic approach for mesothelioma (MMe), its efficacy and tolerability remain questioned. One potential explanation for different responses to immunotherapy is the gut and intratumor microbiota; however, these remain an underexplored facet of MMe. This article highlights the cancer intratumor microbiota as a novel potential prognostic indicator in MMe.MethodsTCGA data on 86 MMe patients from cBioPortal underwent bespoke analysis. Median overall survival was used to divide patients into “Low Survivors” and “High Survivors”. Comparison of these groups generated Kaplan-Meier survival analysis, differentially expressed genes (DEGs), and identification of differentially abundant microbiome signatures. Decontamination analysis refined the list of signatures, which were validated as an independent prognostic indicator through multiple linear regression modelling and Cox proportional hazards modelling. Finally, functional annotation analysis on the list of DEGs was performed to link the data together.Results107 genera signatures were significantly associated with patient survival (positively or negatively), whilst clinical characteristic comparison between the two groups demonstrated that epithelioid histology was more common in “High Survivors” versus biphasic in “Low Survivors”. Of the 107 genera, 27 had published articles related to cancer, whilst only one (Klebsiella) had MMe-related published articles. Functional annotation analysis of the DEGs between the two groups highlighted fatty acid metabolism as the most enriched term in “High Survivors”, whilst for “Low Survivors” the enriched terms primarily related to cell cycle/division. Linking these ideas and findings together is that the microbiome influences, and is influenced by, lipid metabolism. Finally, to validate the independent prognostic value of the microbiome, multiple linear regression modelling as well as Cox proportional hazards modelling were employed, with both approaches demonstrating that the microbiome was a better prognostic indicator than patient age or stage of the cancer.DiscussionThe findings presented herein, alongside the very limited literature from scoping searches to validate the genera, highlight the microbiome and microbiota as a potentially rich source of fundamental analysis and prognostic value. Further in vitro studies are needed to elucidate the molecular mechanisms and functional links that may lead to altered survival.

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Section: Discussionmentioning

confidence: 99%

Intratumor microbiota as a novel potential prognostic indicator in mesothelioma

Pentimalli¹,

Krstic‐Demonacos²,

Costa³

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…On the other hand, benzothiadiazinone dioxides (also called cyclosulfamides) are important heterocyclic-based compounds bearing the sulfamide moiety that is recognized as a remarkable pharmacophore with a high number of applications in the fields of medicinal chemistry and drug development. 16 Different pharmacological activities of cyclic sulfamides were reported in the literature comprising antibacterial, 17 antiviral, 18 anti-inflammatory, 19 and anticancer activities. 20 Further, the high capacity of cyclosulfamides in inhibiting many enzymes and target proteins such as phosphodiesterase 7 (PDE7), 21 aspartic proteases, 22 and serine proteases 23 turned interest of scientists to conceive more molecules containing this scaffold.…”

Section: Introductionmentioning

confidence: 99%