3-MCPD and glycidol coexposure induces systemic toxicity and synergistic nephrotoxicity via NLRP3 inflammasome activation, necroptosis, and autophagic cell death

Liu, Pei Wen; Li, Chung I.; Huang, Kuang‐Chih; Liu, Chiang Shin; Chen, Hsiu-Lin; Lee, Ching Chang; Chiou, Yuan Yow; Chen, Rong Jane

doi:10.1016/j.jhazmat.2020.124241

Cited by 35 publications

(29 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, food consumed as such, or after cooking processes, as well as water, may also contain internal or accidental components with a stimulating effect on NLRP3 inflammasome. Among these, mycotoxins (zearalenone, patulin, deoxynivalenol), trace metals (arsenic, cadmium), environmental and food contaminants (acrolein, 3-monochloropropane-1,2-diol, glycidol, and its esters), and acrylamide are few examples of NLRP3 activators, endowed with harmful inflammatory effects [ 212 , 213 , 214 , 215 , 216 , 217 , 218 , 219 , 220 ].…”

Section: Food and Nutraceuticals Components Bioavailability And Toxicitymentioning

confidence: 99%

Modulatory Properties of Food and Nutraceutical Components Targeting NLRP3 Inflammasome Activation

et al. 2022

View full text Add to dashboard Cite

Inflammasomes are key intracellular multimeric proteins able to initiate the cellular inflammatory signaling pathway. NLRP3 inflammasome represents one of the main protein complexes involved in the development of inflammatory events, and its activity has been largely demonstrated to be connected with inflammatory or autoinflammatory disorders, including diabetes, gouty arthritis, liver fibrosis, Alzheimer’s disease, respiratory syndromes, atherosclerosis, and cancer initiation. In recent years, it has been demonstrated how dietary intake and nutritional status represent important environmental elements that can modulate metabolic inflammation, since food matrices are an important source of several bioactive compounds. In this review, an updated status of knowledge regarding food bioactive compounds as NLRP3 inflammasome modulators is discussed. Several chemical classes, namely polyphenols, organosulfurs, terpenes, fatty acids, proteins, amino acids, saponins, sterols, polysaccharides, carotenoids, vitamins, and probiotics, have been shown to possess NLRP3 inflammasome-modulating activity through in vitro and in vivo assays, mainly demonstrating an anti-NLRP3 inflammasome activity. Plant foods are particularly rich in important bioactive compounds, each of them can have different effects on the pathway of inflammatory response, confirming the importance of the nutritional pattern (food model) as a whole rather than any single nutrient or functional compound.

show abstract

Section: Food and Nutraceuticals Components Bioavailability And Toxicitymentioning

confidence: 99%

Modulatory Properties of Food and Nutraceutical Components Targeting NLRP3 Inflammasome Activation

et al. 2022

View full text Add to dashboard Cite

show abstract

“…As described above, autophagy is induced by various cellular stressors [ 62 ]. Notably, autophagy can also act as a double-edged sword depending on cell and disease conditions [ 63 , 64 , 65 ]. In this review, we further discuss the roles of autophagy in the regulation of diseases, particularly those of the kidneys, neurons, and immune system.…”

Section: The Role Of Autophagy In the Health-promoting Effects Of Cordycepinmentioning

confidence: 99%

“…For instance, WNT family member 1 (WNT1)-induced signaling pathway protein-1 (WISP-1), Myc, CCAAT-enhancer-binding protein (C/EBP), and protein kinase C alpha (PKCα) can accelerate the development of renal fibrosis by increasing autophagic flux in the UUO-induced mouse model and TGF-β-stimulated tubular epithelial cells [ 80 , 81 , 82 , 83 ]. In fact, we previously reported that kidney damage along with fibrosis is observed in mice exposed to food contaminant 3-monochloropropane-1,2-diol (3-MCPD) and glycidol alone or in combination [ 63 ]. Autophagic cell death, necroptosis, and pyroptosis occur simultaneously in damaged kidney tissues and tubular cell lines as well [ 63 ].…”

Section: The Role Of Autophagy In the Health-promoting Effects Of Cordycepinmentioning

confidence: 99%

“…In fact, we previously reported that kidney damage along with fibrosis is observed in mice exposed to food contaminant 3-monochloropropane-1,2-diol (3-MCPD) and glycidol alone or in combination [ 63 ]. Autophagic cell death, necroptosis, and pyroptosis occur simultaneously in damaged kidney tissues and tubular cell lines as well [ 63 ]. Therefore, we proposed that an interaction existed between autophagic cell death and other cell modalities, which thereafter contributed to kidney toxicity by 3-MCPD and glycidol coexposure [ 63 ].…”

Section: The Role Of Autophagy In the Health-promoting Effects Of Cordycepinmentioning

confidence: 99%

“…Autophagic cell death, necroptosis, and pyroptosis occur simultaneously in damaged kidney tissues and tubular cell lines as well [ 63 ]. Therefore, we proposed that an interaction existed between autophagic cell death and other cell modalities, which thereafter contributed to kidney toxicity by 3-MCPD and glycidol coexposure [ 63 ].…”

Section: The Role Of Autophagy In the Health-promoting Effects Of Cordycepinmentioning

confidence: 99%

See 2 more Smart Citations

The Role of Autophagy in Anti-Cancer and Health Promoting Effects of Cordycepin

Chen

Lin

et al. 2021

Molecules

Self Cite

View full text Add to dashboard Cite

Cordycepin is an adenosine derivative isolated from Cordyceps sinensis, which has been used as an herbal complementary and alternative medicine with various biological activities. The general anti-cancer mechanisms of cordycepin are regulated by the adenosine A3 receptor, epidermal growth factor receptor (EGFR), mitogen-activated protein kinases (MAPKs), and glycogen synthase kinase (GSK)-3β, leading to cell cycle arrest or apoptosis. Notably, cordycepin also induces autophagy to trigger cell death, inhibits tumor metastasis, and modulates the immune system. Since the dysregulation of autophagy is associated with cancers and neuron, immune, and kidney diseases, cordycepin is considered an alternative treatment because of the involvement of cordycepin in autophagic signaling. However, the profound mechanism of autophagy induction by cordycepin has never been reviewed in detail. Therefore, in this article, we reviewed the anti-cancer and health-promoting effects of cordycepin in the neurons, kidneys, and the immune system through diverse mechanisms, including autophagy induction. We also suggest that formulation changes for cordycepin could enhance its bioactivity and bioavailability and lower its toxicity for future applications. A comprehensive understanding of the autophagy mechanism would provide novel mechanistic insight into the anti-cancer and health-promoting effects of cordycepin.

show abstract

Pre‐deacidification of hazelnut oil by short‐path distillation: Changes in 3‐chloropropane‐1,2‐diol esters, glycidyl esters, free fatty acids, tocopherols, and diglycerides

Kantekin-Erdogan

Emektar

VARDİN

et al. 2023

Euro J Lipid Sci & Tech

View full text Add to dashboard Cite

Performing pre‐deacidification using short‐path distillation at high temperatures and vacuum levels is a general application for fats and oils with high free fatty acids (FFA) to reduce their FFA contents to reasonable levels before steam distillation or neutralization. This study aims to determine the changes in 3‐chloropropane‐1,2‐diol esters (3‐MCPDE), glycidyl esters (GE), and diglyceride (DG) as well as the losses in tocopherols during this process. A bleached hazelnut oil having 12.10% FFA content was distilled using a molecular distillation unit at 200 °C, 220 °C, and 240°C temperatures and 0.25, 0.5, 1, and 2 mbar absolute pressures. The target was to reduce FFA content to less than 2% with minimum tocopherol loss. The results showed that considerable removals in FFA and GE contents were achieved by increasing the temperature and vacuum, while fewer decreases were detected in 3‐MCPDE and DG concentrations. Tocopherols were dramatically decreased by temperature rising, therefore, the lowest temperature (200°C) and absolute pressures (0.25–0.5 mbar) might be suitable for pre‐deacidification of hazelnut oil, where the distilled oil contained 1.78%–1.90% FFA, 243.11–286.76 mg kg–1 tocopherol, 0.50–0.55 mg kg–1 3‐MCPDE, 0.03–0.05 mg kg–1 GE and 4.00–4.22 mg kg–1 DG.Practical Application: Vegetable oils with high free fatty acid (FFA) contents are generally subjected to physical refining to avoid considerable refining loss. However, high temperatures applied to vegetable oils during physical refining result in the formation of 3‐MCPDE&GE, and the loss of some nutrients, such as tocopherols. These adverse effects can be reduced through application of lower temperatures and shorter time during physical refining. This can be applied after the FFA contents of the oils are decreased to reasonable levels (less than 2%) by distillation (pre‐deacidification) before the deodorization. Although this technique has been implemented in many plants, there is almost no information on the effects of applied conditions on 3‐MCPDE and GE and some other minor constituents. This manuscript explains the changes in these compounds during the pre‐deacidification of hazelnut oil by molecular distillation. Suitable distillation conditions were also suggested, which would be very useful for industrial refining plants.

show abstract

3-MCPD and glycidol coexposure induces systemic toxicity and synergistic nephrotoxicity via NLRP3 inflammasome activation, necroptosis, and autophagic cell death

Cited by 35 publications

References 30 publications

Modulatory Properties of Food and Nutraceutical Components Targeting NLRP3 Inflammasome Activation

Modulatory Properties of Food and Nutraceutical Components Targeting NLRP3 Inflammasome Activation

The Role of Autophagy in Anti-Cancer and Health Promoting Effects of Cordycepin

Pre‐deacidification of hazelnut oil by short‐path distillation: Changes in 3‐chloropropane‐1,2‐diol esters, glycidyl esters, free fatty acids, tocopherols, and diglycerides

Contact Info

Product

Resources

About