3-Monochloropropandiol and glycidyl esters in heat-processed oil-based food products: Exposure and risk

Yabani, Daniel Sitsofe; Ofosu, Isaac Williams; Ankar-Brewoo, Gloria Mathanda; Lutterodt, Herman Erick

doi:10.1016/j.afres.2024.100393

Applied Food Research

2024

DOI: 10.1016/j.afres.2024.100393

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3-Monochloropropandiol and glycidyl esters in heat-processed oil-based food products: Exposure and risk

Daniel Sitsofe Yabani,

Isaac Williams Ofosu,

Gloria Mathanda Ankar-Brewoo

et al.

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2024

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Cited by 2 publications

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Public health risks associated with food process contaminants - a review

Zahir,

Ge,

Khan

2024

Journal of Food Protection

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Public health risks associated with food process contaminants - a review

Zahir,

Ge,

Khan

2024

Journal of Food Protection

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Toxicity of Dietary Exposure to 3‐Monochloropropanediol, Glycidol, and Their Fatty Acid Esters

Yabani,

Ofosu,

Ankar-Brewoo

et al. 2024

Journal of Food Quality

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3‐Monochloropropane‐1,2‐diol (3‐MCPD), 2,3‐epoxy‐1‐propanol (glycidol), and their fatty acid esters are heat‐induced food toxicants that have widely been investigated. This review study presents an overview of current knowledge about the dietary toxicity of 3‐MCPD, glycidol, and their fatty acid esters. A literature search in two databases from January 2012 to December 2023 yielded 75 eligible articles for this review. The majority (73%) of the articles focused on 3‐MCPD‐ and 3‐MCPD fatty acid ester‐induced toxicities. Nephrotoxicity (32%) was the most studied toxicity, whereas the least studied were carcinogenicity (4%) and hematotoxicity (4%). The metabolism of glycidol and its esters to 3‐MCPD in the gastrointestinal tract remained a subject of contention as studies reported opposing findings. There was also new evidence of 3‐MCPD‐induced reproductive toxicity, hematotoxicity, and nephrotoxicity and 3‐MCPD‐ and glycidol‐induced neurotoxicity and genotoxicity. Findings suggest animal species‐dependency in 3‐MCPD’s carcinogenicity expression. Meanwhile, the 3‐MCPD toxicity mechanism in obese rats is poorly understood. The review recommends further studies into the 3‐MCPD toxicity mechanism in obese rats and the possible conversion of glycidol to 3‐MCPD in gastrointestinal tracts.

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3-Monochloropropandiol and glycidyl esters in heat-processed oil-based food products: Exposure and risk

Cited by 2 publications

References 41 publications

Public health risks associated with food process contaminants - a review

Public health risks associated with food process contaminants - a review

Toxicity of Dietary Exposure to 3‐Monochloropropanediol, Glycidol, and Their Fatty Acid Esters

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