3.P.135 Evidence for a lipid microphage separation in human low density lipoprotein

Lipoprotein Structure and Dynamics: Low Density Lipoprotein Viewed as a Highly Dynamic and Flexible Nanoparticle

“…For comprehensive reviews on different biophysical studies applied on LDL species see refs. [30,31]. In recent years structural investigations using cryo-e.m. reconstruction techniques have become prevalent and with time 3-dimensional models with improved resolution were presented [32][33][34][35][36][37].…”

Blood lipoproteins: key bio-nanoparticles defying crystallography need hybrid approach

“…the synergistic application of different structural, spectroscopic and thermodynamic methods has been successfully applied. [3] SAXS, SANS, and electron microscopy have played pivotal roles towards the understanding of size, shape and internal organization, while spectroscopic methods like spin-label ESR, NMR and fluorescence microscopy have contributed important information on internal short range organization and dynamics. Thermotropic transitions, and the effects of cholesterol lowering drugs thereon, were analyzed by calorimetry.…”