3-Pyridylisoxazoles as prototypes of antiaggregatory agents

5′-Substituted Indoline Spiropyrans: Synthesis and Applications

“…A library of more than 120 compounds of classes of 3,5-substituted isoxazoles and their 4,5-dihydroderivatives containing 2-, 3-, and 4-pyridine moieties at the C3-position and substituents of different nature at the C5-position of the isoxazole ring was produced. To study the action mechanism of this class of human platelet aggregation inhibitors, three compounds containing the molecular address in a different spatial orientation to a fragment of a photochromic label from the series of spiropyrans were synthesized, and the process of their binding with human platelet membrane receptors was explored [85,93,94]. (c).…”

“…The photochromic properties of pyrrolidinofullerene To develop the photochromic labels for the non-covalent affinity binding of a probe molecule to a target through a "molecular address", it was necessary to develop a method for introducing a "molecular address" fragment into a certain position of the label molecule, as a fragment of 3,5-substituted isoxazole and their 4,5-dihydroderivative, containing 3pyridine fragment in the C3-position, with varying orientation relative to the photochromic fragment. To study the action mechanism of this class of human platelet aggregation inhibitors, three photoactive thromboxane A 2 receptor inhibitors (compounds SP233-SP235), were synthesized starting from SP94 by [3+2]cycloaddition reaction as key step, and the process of their binding with human platelet membrane receptors was explored (see Figures 15,17H and 18B and [85,93,94].…”