3-Quinuclidinyl-α-methoxydiphenylacetate: A multi-targeted ligand with antimuscarinic and antinicotinic effects designed for the treatment of anticholinesterase poisoning

Timperley, Christopher M.; Bird, Michael R.; Gore, Samuel J.; Lindsay, Christopher D.; Rice, Helen; Tattersall, J.E.H.; Whitmore, C.; Green, A. Christopher

doi:10.1016/j.toxlet.2020.01.027

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General Procedures B For the Synthesis Of Methyl 2-chloro-2-...1

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“…1H NMR (300 MHz, CDCl3) δ 7.42–7.26 (m, 10H, C H Ar ), 3.78 (s, 3H, C H 3 ). Spectroscopic data were in agreement with those previously reported [ 32 ].…”

Section: Methodssupporting

confidence: 91%

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Synthesis of α-Chloroarylacetic Acid via Electrochemical Carboxylation of α,α-Dichloroarylmethane Derivatives

Maret,

David,

Pierrot

et al. 2023

Molecules

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The electrocarboxylation of α,α-dichloroarylmethane derivatives in the presence of CO2 was achieved, providing several α-chloroarylacetic acid derivatives with modest yields but high selectivity (chlorinated vs. non-chlorinated or dicarboxylic acid products). The obtained products were then involved in several chemical transformations, underlining their potential as versatile intermediates in synthetic chemistry. A mechanism was also proposed based upon a control experiment and cyclic voltammetry (CV) study.

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“…1H NMR (300 MHz, CDCl3) δ 7.42–7.26 (m, 10H, C H Ar ), 3.78 (s, 3H, C H 3 ). Spectroscopic data were in agreement with those previously reported [ 32 ].…”

Section: Methodssupporting

confidence: 91%

“…1H NMR (300 MHz, CDCl3) δ 7.42-7.26 (m, 10H, CH Ar ), 3.78 (s, 3H, CH 3 ). Spectroscopic data were in agreement with those previously reported [32]. Compound 10 was obtained after a slight modification of the general procedure A.…”

Section: General Procedures B For the Synthesis Of Methyl 2-chloro-2-...supporting

confidence: 87%