3′ untranslated region A&gt;C (rs3212227) polymorphism of Interleukin 12B gene as a potential risk factor for Hodgkin’s lymphoma in Brazilian children and adolescents

Silva, B O; Correia, Ana; Barros, Tânia Fraga; Lima, Luísa Priscilla Oliveira de; Morais, Anabela; Hassan, Rowa; Dellalibera, Edileine; Cavalcanti, María Auxiliadora de Queiroz; Muniz, Maria Tereza Cartaxo

doi:10.1055/s-0040-1701839

Cited by 3 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To evaluate the distribution between the clinical and biological characteristics of the patients, some variables were categorized into groups: age (≤10 and >10 years), 20 risk group (favorable and unfavorable), 20 histopathology (CHL and NLPHL) 20 and staging (I/II and III/IV). 8…”

Section: Resultsmentioning

confidence: 99%

Increased expression of matrix metalloproteinases 2 and 9 as poor prognosis factor for Hodgkin's lymphoma patients

Silva¹,

Medeiros²,

Albuquerque³

et al. 2023

Jornal de Pediatria

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

Increased expression of matrix metalloproteinases 2 and 9 as poor prognosis factor for Hodgkin's lymphoma patients

Silva¹,

Medeiros²,

Albuquerque³

et al. 2023

Jornal de Pediatria

View full text Add to dashboard Cite

“…Also, several studies investigated the effect of the IL‐12B rs3212227 (A/C) [located in 3′ untranslated region (UTR) of IL‐12B gene at position chr5:159315942] on IL‐12 p40 expression and secretion, possibly due to the effects of this region on IL‐12 gene expression, protein synthesis, and, consequently, predisposition to various disorders. It has been hypothesized that this SNP may result in post‐transcriptional modifications of IL‐12B gene expression by interfering with ribosomal polypeptide synthesis, thereby altering the cytokine's production (Silva et al., 2019). As for IL‐12Rβ2 rs3790565(C/T) (located in the intron of IL‐12Rβ2 gene at position chr1:67345673), several studies have suggested that this SNP may have immunoregulatory functions, resulting in a modification of inflammatory responses, especially those mediated by IL‐12 (Hirschfield et al., 2009).…”

Section: Introductionmentioning

confidence: 99%

Association between gene polymorphisms of IL‐12, IL‐12 receptor and IL‐27 and organ involvement in Iranian endometriosis patients

Zare

Hesampour

Poordast

et al. 2022

Int J Immunogenetics

View full text Add to dashboard Cite

Endometriosis is an inflammatory disease characterized by the presence of ectopic endometrial tissue, immune cell dysfunction and abnormal cytokine secretion. In addition to immunological factors, genetic variations that influence endometriosis severity and cytokine expression levels play important roles in the pathogenesis of this disease. Interleukin-12 (IL-12), specifically its p40 subunit encoded by IL-12B gene and the interleukin-12 receptor β1 (IL-12Rβ2) chain of its receptor, as well as interleukin-27 (IL-27) are important in the establishment of endometriosis. So, in this study, we measured IL-12 and IL-27 serum levels and investigated the possible links between IL-12B rs3212227, IL-12Rβ2 rs3790565 and IL-27 rs153109 polymorphisms and the risk of developing endometriosis in a group of Iranian women. In this case-control study, 162 endometriosis patients and 151 healthy women were included and tested for the aforementioned polymorphisms using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. The enzyme-linked immunosorbent assay (ELISA) method was also used to measure IL-12 and IL-27 serum levels. Although there was no statistically significant association between the genotypes and alleles of the studied polymorphisms and the development of endometriosis in general, the AA genotype of IL-12B rs3212227 showed a significant association with uterine endometriosis when compared to AC+CC genotypes (p = .04, CI = 0.270-0.988, OR = 0.517). Indeed, the AA genotype of the IL-12B rs3212227 single nucleotide polymorphism (SNP) may be linked with a lower risk of developing uterine endometriosis.There was no significant difference in IL-27 levels between the two studied groups (p = .49), and IL-12 levels were undetectable in both groups. In conclusion, the AA genotype of IL-12B rs3212227 might be associated with a decreased risk of uterine involvement in endometriosis patients.

show abstract

“…One of the key roles played by IL-12 is maintenance of the balance between T helper 1 (Th1) differentiation and T helper 2 (Th2) response from its precursor during viral infections (41). IL-12B is a proinflammatory cytokine, which triggers a Th1 response including IL-10 production (49).…”

Section: Introductionmentioning

confidence: 99%

“…Homozygosity for the A allele at position -1188 of the IL-12 gene has been associated with HCV persistence in Chinese, Caucasian, and Egyptian HCVinfected patients (53). Furthermore, multiple studies have also reported IL-12B -1188 polymorphism to represent a significant risk factor in the occurrence of multiple cancer types including HCC (18,41).…”

Section: Introductionmentioning

confidence: 99%

IL-10 Polymorphisms and Haplotypes Predict Susceptibility to Hepatocellular Carcinoma Occurrence in Patients with Hepatitis C Virus Infection from Northeast India

et al. 2020

View full text Add to dashboard Cite

Chronic hepatitis C virus (HCV) infection leads to variable outcomes, ranging from prolonged slow hepatic damage leading to cirrhosis, and hepatocellular carcinoma (HCC). Polymorphism in cytokines IL-10 and IL-12 that impact the immune response to HCV infection may play a role in determining this outcome. This study was aimed to determine if polymorphisms in IL-10 and IL-12B contribute to HCV susceptibility and the risk of developing HCC in patients from Northeast India. IL-10 -1082, -819, -592 polymorphisms and IL-12B -1188 polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism in a total of 266 HCV-infected patients and 100 age-and sex-matched controls. In the HCV-infected subjects, 110 patients had chronic hepatitis C (CHC), 96 with liver cirrhosis, and 60 with HCC. Serum levels of IL-10 were also measured and correlated with disease severity. Haplotype analysis for IL-10 polymorphisms was carried out. Statistical data were analyzed using SPSS ver. 22.0. The frequency of IL-10 -592 AA genotype/A allele was significantly higher in HCC patients than in CHC patients. The intermediate IL-10-producing ACC haplotype was significantly more frequent in HCC and cirrhotic patients than in CHC patients. No significant association was found for IL-10 -819, -592 and IL-12B -1188 polymorphisms with the susceptibility to HCV infection or occurrence of HCC in HCV-infected patients. IL-10 -592 CA polymorphism and IL-10 ACC haplotype are significant biomarkers of HCC in HCV-infected patients from Northeast India. Higher serum levels of IL-10 were also linked to higher disease severity.

show abstract

3′ untranslated region A>C (rs3212227) polymorphism of Interleukin 12B gene as a potential risk factor for Hodgkin’s lymphoma in Brazilian children and adolescents

Cited by 3 publications

References 0 publications

Increased expression of matrix metalloproteinases 2 and 9 as poor prognosis factor for Hodgkin's lymphoma patients

Increased expression of matrix metalloproteinases 2 and 9 as poor prognosis factor for Hodgkin's lymphoma patients

Association between gene polymorphisms of IL‐12, IL‐12 receptor and IL‐27 and organ involvement in Iranian endometriosis patients

IL-10 Polymorphisms and Haplotypes Predict Susceptibility to Hepatocellular Carcinoma Occurrence in Patients with Hepatitis C Virus Infection from Northeast India

Contact Info

Product

Resources

About