30-day and 60-day rates and predictors of mortality among adult stroke patients: Prospective cohort study

Fekadu, Ginenus; Chelkeba, Legese; Melaku, Tsegaye; Tegene, Elsah; Kebede, Ayantu

doi:10.1016/j.amsu.2020.03.001

Cited by 13 publications

(16 citation statements)

References 62 publications

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“…Likewise, the 30-day survival rate 81.39% of this study is higher than 69.8% survival rate of Jimma at one month. 46 The difference might be due to the study design at Jimma. It was a prospective study and assessed by close follow-up of the patient through telephone interview of the patient/caregiver after patients were discharged from the hospital, which can determine the true survival rate.…”

Section: Discussionmentioning

confidence: 99%

The Survival Status and Predictors of Mortality Among Stroke Patients at North West Ethiopia

Walelgn¹,

Abyu²,

Seyoum³

et al. 2021

RMHP

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Introduction: Stroke is one of the commonest non-communicable disease types that has a great public health impact both in developed and developing countries. However, in Ethiopia, the long-term survival status of stroke patients is not very understood. This study aimed at assessing survival status and predictors of mortality among stroke patients at Felege Hiwot comprehensive specialized hospital from September 1, 2014, to August 31, 2019, Bahirdar, North West Ethiopia. Methods: An institutional-based retrospective cohort study was conducted using 368 registered stroke patients between September 1, 2014, and August 31, 2019. We used Kaplan-Meier together with a Log-rank test to compare the survival rate of the study participants using categorical variables and to compare covariate and both bi-variable and multivariable Cox proportional hazards regression analysis model was conducted to identify predictors of mortality among stroke patients. The association between outcome and independent variables was expressed using an adjusted hazard ratio (AHR) with a 95% confidence interval and statistical significances were declared at P-value of <0.05. Results: Fifty-six (15.2%) of the 368 stroke patients included in the study died, and 312 (84.8%) were correctly censored. The overall survival rate was 72.2% at 51 months of follow-up with a median survival time of 0.26 months. Age greater than 65 (AHR 6.31, 95% CI 1.75-22.74), body temperature >7.1 degree centigrade (AHR = 7.14, 95% CI: 2.76-18.5), potassium level below <2 mmol/l (AHR = 2, 95% CI: 1.9-23.53) and creatinine level >1.2 mg/dl (AHR = 7.85, 95% CI: 2.7-22.6) were predictive predictors of mortality. Conclusions: In the follow-up of 51 months, significant mortality occurred. Important predictive predictors of survival status were identified. Interventions should be focused on health education and awareness creation of the community for the early management of stroke.

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Section: Discussionmentioning

confidence: 99%

The Survival Status and Predictors of Mortality Among Stroke Patients at North West Ethiopia

Walelgn¹,

Abyu²,

Seyoum³

et al. 2021

RMHP

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“…This finding is in line with several prior studies which reported that ischemic stroke was more prevalent than hemorrhagic strokes. 13,18,19 On the other hand, there are studies from Ethiopia that reported equal prevalence of both stroke subtypes or high prevalence of hemorrhagic stroke. [23][24][25] This discrepancy could be due to differences in stroke diagnosis (clinical vs neuroimaging), population-level socio-economics and risk factors.…”

Section: Discussionmentioning

confidence: 99%

“…12 Even if thrombolytic drugs are available low awareness of stroke symptoms by society and prolonged pre-hospital delay exclude most stroke patients from receiving r-tPA. 13,14 This is due to the fact that fibrinolytic therapy has been proven to be beneficial if administered within 4.5 h after the onset of an ischemic stroke. 15 Yet patients with large vessel occlusion will benefit from thrombolytic therapy beyond 6 h and up to 24 h since stroke onset.…”

Section: Introductionmentioning

confidence: 99%

Pharmacotherapy Pattern and Treatment Outcomes of Stroke Patients Admitted to Jimma University Medical Center, Ethiopia

Beyene¹,

Fanta²,

Tatiparthi³

2021

PROM

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Background: Despite the fact that stroke has been reported as one of the top three leading causes of death and morbidity in Ethiopia, there are limited data regarding the management of stroke and clinical outcomes. Hence, the present study aimed to evaluate the pharmacotherapy of stroke and factors associated with poor treatment outcomes. Methods: A retrospective cross-sectional study was conducted at Jimma University Medical Center (JUMC) among adult stroke patients managed from 2014 to 2017. Clinical characteristics, treatment, and outcomes data were analyzed by using SPSS version 21. Multivariable logistic regression was performed to identify the predictors of poor treatment outcomes. Two-sided P < 0.05 was accepted as statistically significant. Results: A total of 153 illegible patient cases were included in this study. The majority, 111 (72.5%), were male and the mean age of the patients was 57±13.7 years. Among 153 stroke patients, 112 (73.2%) patients presented with ischemic stroke. Aspirin and statins (78.6%) were the most commonly used treatment among ischemic stroke patients, whereas enalapril was used in about (43%) of stroke patients to treat high blood pressure. About 61 (40%) stroke patients had poor treatment outcomes; of this, 36 (23.5%) died in hospital. Older age (AOR = 1.034; 95% CI: 1.003-1.069), history of heart failure (AOR = 4.26; 95% CI: 1.58-11.48), loss of consciousness diabetes (AOR = 3.05 95% CI: 1.25-7.44), and aspiration pneumonia (AOR = 5.94; 95% CI: 2.46-14.32) were significantly associated with poor treatment outcomes. Conclusion: Overall, treatment of stroke patients was sub-optimal and almost half of the patients had poor treatment outcomes. Availing of thrombolytic therapy, devising appropriate preventive measures of risk factors (hypertension), and decreasing preventable complication such as aspiration pneumonia could improve patient outcomes.

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“…Stroke is one of the leading and preventable causes of sudden death and the most common cause of long-term disability worldwide [ 73 , 74 ]. Ischemic stroke (IS) accounts for approximately 80–85% of stroke cases against haemorrhagic one [ 75 , 76 ].…”

Section: Ischemic Lesions and Strokementioning

confidence: 99%

Cell-free nucleic acid patterns in disease prediction and monitoring—hype or hope?

et al. 2020

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Interest in the use of cell-free nucleic acids (CFNAs) as clinical non-invasive biomarker panels for prediction and prevention of multiple diseases has greatly increased over the last decade. Indeed, circulating CFNAs are attributable to many physiological and pathological processes such as imbalanced stress conditions, physical activities, extensive apoptosis of different origin, systemic hypoxic-ischemic events and tumour progression, amongst others. This article highlights the involvement of circulating CFNAs in local and systemic processes dealing with the question, whether specific patterns of CFNAs in blood, their detection, quantity and quality (such as their methylation status) might be instrumental to predict a disease development/progression and could be further utilised for accompanying diagnostics, targeted prevention, creation of individualised therapy algorithms, therapy monitoring and prognosis. Presented considerations conform with principles of 3P medicine and serve for improving individual outcomes and cost efficacy of medical services provided to the population.

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30-day and 60-day rates and predictors of mortality among adult stroke patients: Prospective cohort study

Cited by 13 publications

References 62 publications

The Survival Status and Predictors of Mortality Among Stroke Patients at North West Ethiopia

The Survival Status and Predictors of Mortality Among Stroke Patients at North West Ethiopia

Pharmacotherapy Pattern and Treatment Outcomes of Stroke Patients Admitted to Jimma University Medical Center, Ethiopia

Cell-free nucleic acid patterns in disease prediction and monitoring—hype or hope?

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