30-Day Mortality in Acute Pulmonary Embolism: Prognostic Value of Clinical Scores and Anamnestic Features

Bach, Andreas; Taute, Bettina-Maria; Nansalmaa, Baasai; Wienke, Andreas; Meyer, Hans Jonas; Schramm, Dominik

doi:10.1371/journal.pone.0148728

Cited by 24 publications

(26 citation statements)

References 16 publications

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“…However, the study cohort consisted of moderately ill patients and was performed in a pulmonary clinic outside of ICU. Bach et al compared the prognostic yield of different scoring systems and found that APACHE II score performed better than PESI and simplified PESI [19]. The good predictive yield of APACHE II in the critically ill depends on the global assessment of the patient.…”

Section: Discussionmentioning

confidence: 99%

Mortality Related Risk Factors in High-Risk Pulmonary Embolism in the ICU

Ergan

Ergün

Çalışkan

et al. 2016

Canadian Respiratory Journal

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Introduction. We sought to identify possible risk factors associated with mortality in patients with high-risk pulmonary embolism (PE) after intensive care unit (ICU) admission. Patients and Methods. PE patients, diagnosed with computer tomography pulmonary angiography, were included from two ICUs and were categorized into groups: group 1 high-risk patients and group 2 intermediate/low-risk patients. Results. Fifty-six patients were included. Of them, 41 (73.2%) were group 1 and 15 (26.7%) were group 2. When compared to group 2, need for vasopressor therapy (0 vs 68.3%; p < 0.001) and need for invasive mechanical ventilation (6.7 vs 36.6%; p = 0.043) were more frequent in group 1. The treatment of choice for group 1 was thrombolytic therapy in 29 (70.7%) and anticoagulation in 12 (29.3%) patients. ICU mortality for group 1 was 31.7% (n = 13). In multivariate logistic regression analysis, APACHE II score >18 (OR 42.47 95% CI 1.50–1201.1), invasive mechanical ventilation (OR 30.10 95% CI 1.96–463.31), and thrombolytic therapy (OR 0.03 95% CI 0.01–0.98) were found as independent predictors of mortality. Conclusion. In high-risk PE, admission APACHE II score and need for invasive mechanical ventilation may predict death in ICU. Thrombolytic therapy seems to be beneficial in these patients.

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Section: Discussionmentioning

confidence: 99%

Mortality Related Risk Factors in High-Risk Pulmonary Embolism in the ICU

Ergan

Ergün

Çalışkan

et al. 2016

Canadian Respiratory Journal

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“…Acute pulmonary embolism is one of the three major cardiovascular diseases along with cardiac and cerebral infarction and it has a high 30-day mortality rate in the order of ten percent (1,2). In general, typical symptoms such as shock, dyspnea and chest pain are caused by central pulmonary emboli at a higher frequency.…”

Section: Introductionmentioning

confidence: 99%

Fan-shaped ground-glass opacity (GGO) as a premonitory sign of pulmonary infarction: a case report

et al. 2018

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Radiological findings of pulmonary infarction have been well characterized mainly in established infarction. However, the early course CT appearance of patients who develop pulmonary infarction has not yet been fully elucidated. A 50-year-old female with a history of postmenopausal hormone replacement therapy (HRT) presented with dry cough and high-resolution computed tomography (HRCT) findings of fan-shaped segmental ground-glass opacity (GGO) in the right lower lobe. As the parenchymal density in the GGO gradually enlarged over a period of 4 weeks in spite of antibiotic treatment, the patient was referred to our hospital on clinical suspicion of bronchioloalveolar cell carcinoma. However, the pathological findings of a transbronchial biopsy of the lesion were compatible with pulmonary infarction. After an endoscopic examination, the typical CT appearance of established pulmonary infarction was observed. Moreover, enhanced CT detected an intraluminal filling defect in the right lower lobe artery suggesting peripheral pulmonary emboli. Our case was a peripheral pulmonary infarction probably induced by HRT, and suggested that fan-shaped GGO may be a premonitory sign of pulmonary infarction.

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“…Während der ambulanten Weiterbehandlung erhöht sich das Mortalitätsrisiko durch thromboembolische Folgeereignisse und Nebenwirkungen der Therapie, sowie durch Rechtsherzversagen bei Patienten mit persistierender pulmonaler Hypertonie. Die kumulative Mortalität nach 30 Tagen, bezogen auf alle Schweregrade, wird im Mittel mit etwas mehr als 10 % angegeben (4,12,26,58,90).…”

Section: Hintergrundinformationen Zur Lungenembolieunclassified

Lungenszintigraphie (Version 3)

Schümichen¹,

Schmidt²,

Krause³

2018

Nuklearmedizin

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ZusammenfassungIn der aktualisierten und erweiterten S1-Leitlinie zur Lungenszintigraphie werden die Vorzüge der Methode beim Nachweis der akuten Lungenembolie (LE) in der Lungenperipherie (subsegmentale LE), bei subakuten und chronischen Grunderkrankungen der Lunge, sowie beim Nachweis der chronischen LE (CTEPH) herausgestellt. Methode der Wahl ist die Ventilations/Perfusions(V/P)-SPECT oder V/P-SPECT/CT mit nochmals gesteigerter Spezifität. Aufgrund der hohen Sensitivität wird, um eine Übertherapie zu vermeiden, ein Schwellenwert eingeführt (V/P-mismatch in mindestens einem Segment oder zwei Subsegmenten). Im Falle eines veränderten Therapieverhaltens (nur Observation anstelle Antikoagulation) kann der Schwellenwert entfallen. Zur klinisch-therapeutischen Wertigkeit von subsementalen LE werden neue Daten präsentiert, die Kapitel offene Fragen wurden erweitert. Die weiteren Indikationen für V/P-SPECT (Nebendiagnosen, Anomalien der Lungenperfusion, Voraussage der postoperativen Lungenfunktion) werden mit neueren Daten hinterlegt.

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30-Day Mortality in Acute Pulmonary Embolism: Prognostic Value of Clinical Scores and Anamnestic Features

Cited by 24 publications

References 16 publications

Mortality Related Risk Factors in High-Risk Pulmonary Embolism in the ICU

Mortality Related Risk Factors in High-Risk Pulmonary Embolism in the ICU

Fan-shaped ground-glass opacity (GGO) as a premonitory sign of pulmonary infarction: a case report

Lungenszintigraphie (Version 3)

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