30% supramolecular salicylic acid peels effectively treats acne vulgaris and reduces facial sebum

Zhang, Lingzhao; Shao, Xinyi; Chen, Yangmei; Wang, Jiawei; Ariyawati, Asoka; Zhang, Yujie; Chen, Jiayi; Liu, Lin; Pu, Yihuan; Li, Yuxin; Chen, Jin

doi:10.1111/jocd.14799

Cited by 12 publications

(7 citation statements)

References 33 publications

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“…Large pores are common skin problems associated with excessive sebum secretion [41]. Salicylic acid can dissolve excess oil secreted by the skin and is often used to control sebum secretion [42,43]. Its mechanism of regulating skin oil secretion is downregulating SREBP-1 and NF-κB pathways of SEB-1 sebocytes.…”

Section: Discussionmentioning

confidence: 99%

Preparation and efficacy verification of three‐dimensional printed partitioned multi‐effect precision‐care gel facial mask

Chen,

Liufu,

Zhang

et al. 2024

Intern J of Cosmetic Sci

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ObjectiveA partition multi‐effect precision‐care gel facial mask conforming to facial skin characteristics was prepared using three‐dimensional (3D) printing technology.MethodsFirst, the hydrogel matrix and humectant of a 3D‐printed gel for facial masks were screened, and three 3D‐printed gels of arbutin, hexapeptide, and salicylic acid were prepared with whitening, wrinkle removal, and oil control functions, respectively. Skin irritation tests were performed on the gels. Physicochemical properties such as pH, heat and cold tolerance were evaluated. The efficacy of three 3D‐printed gels was assessed by measuring melanin value, wrinkle depression score, and oil secretion. Finally, the facial mask model design and printing parameters were studied, and a partition multi‐effect precision‐care gel facial mask was printed in line with facial skin characteristics.ResultsFor the 3D‐printed facial mask, the gel prescription with 2% hydroxyethyl cellulose gel as matrix and 7% glycerol as humectant was the best. The prepared 3D‐printed gel did not irritate the human skin, and its physicochemical properties met the Chinese facial mask industry standard (QB/T2872‐2017). We showed that three types of 3D‐printed gels containing arbutin, hexapeptide, and salicylic acid could be applied to the corresponding parts of the face to solve different problems, such as facial skin dullness, wrinkles, and oil secretion. Therefore, according to facial physiological characteristics, the facial mask model was designed for the forehead and nasolabial fold, which needs to be anti‐wrinkled; the cheek, which needs to be whitened; and the nose and chin, which need oil control. The optimal printing parameters were 0.26 mm nozzle diameter, 90 mm/s printing speed, 30% filling density, 140% wire extrusion ratio, and 0.25 mm layer height. Different skin care effects can be achieved using a three‐nozzle printer to print arbutin, hexapeptide, or salicylic acid gel on the mask's forehead and nasolabial fold, cheek, and nose and chin, respectively.ConclusionThe 3D‐printed partition multi‐effect care gel facial mask prepared according to the skin features of different parts of the face can overcome the problem of the single skincare effect of the mass‐produced facial masks.

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Section: Discussionmentioning

confidence: 99%

Preparation and efficacy verification of three‐dimensional printed partitioned multi‐effect precision‐care gel facial mask

Chen,

Liufu,

Zhang

et al. 2024

Intern J of Cosmetic Sci

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“… 20 Clinical investigations have already revealed that transepidermal water loss (TEWL), a measure of skin barrier impairment, either decreased or showed no statistical difference after 30% supramolecular SA chemical peeling 4 times with 2-week intervals. 12 , 24 However, there is little research on the safety evaluation of long-term consecutive SA application with relatively low concentration and its impacts on the epidermal barrier. In our study, we discovered that following topical SA treatment with doses ranging from 0.5% to 5% for 14 days and 28 days, there were no prominent alterations in the gross appearance of murine dorsal skin.…”

Section: Discussionmentioning

confidence: 99%

0.5–5% Supramolecular Salicylic Acid Hydrogel is Safe for Long-Term Topical Application and Improves the Expression of Genes Related to Skin Barrier Homeostasis in Mice Models

Zhou¹,

Hua²,

Liang³

et al. 2023

DDDT

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Background As a keratolytic, salicylic acid (SA) can be topically applied in various formulations and doses in dermatology. Supramolecular SA hydrogel, a new SA formulation with higher bioavailability, is developed and commercially available nowadays. However, there still remain concerns that the long-term and continual application of SA at low concentrations may jeopardize the cutaneous barrier properties. Aim of the Study To reveal the long-term effects of 0.5–5% supramolecular SA hydrogel on the skin barrier in normal mice models. Materials and Methods The 0.5%, 1%, 2%, and 5% supramolecular SA hydrogel or hydrogel vehicle without SA was applied to mice’s shaved dorsal skin once per day respectively. Tissue samples of the dorsal skin were harvested on day 14 and 28 of the serial application of SA for histopathological observation and transcriptomic analysis. Results Following topical supramolecular SA hydrogel therapy with various concentrations of SA (0.5%, 1%, 2%, and 5%) for 14 days and 28 days, there were no obvious macroscopic signs of impaired cutaneous health and no inflammatory or degenerative abnormalities were observed in histological results. Additionally, the transcriptomic analysis revealed that on day 14, SA dramatically altered the expression of genes related to the extracellular matrix structural constituent. And on day 28, SA regulated gene expression profiles of keratinization, cornified envelope, and lipid metabolism remarkably. Furthermore, the expression of skin barrier related genes was significantly elevated after the application of SA based on RNA-seq results, and this is likely to be associated with the PPAR signaling pathway according to the enrichment analysis. Conclusion Our findings demonstrated that the sustained topical administration of the 0.5–5% supramolecular SA hydrogel for up to 28 days did no harm to normal murine skin and upregulated the expression of genes related to the epidermal barrier.

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“…In a previous study, we found that 30% SSA was a safe and effective treatment for AV and could reduce sebum production [ 19 ]. However, very few studies have explored the role of SSA in the treatment of skin microbiota and inflammation in patients with moderate-to-severe AV.…”

Section: Introductionmentioning

confidence: 99%

Effect of 30% Supramolecular Salicylic Acid Peel on Skin Microbiota and Inflammation in Patients with Moderate-to-Severe Acne Vulgaris

Shao

Chen

Zhang

et al. 2022

Dermatol Ther (Heidelb)

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Introduction: Thirty-percent supramolecular salicylic acid (SSA), a modified salicylic acid preparation, is a safe and effective treatment for moderate-to-severe acne vulgaris (AV). However, its mechanism of action remains unclear. We aimed to analyze the role of 30% SSA peels on skin microbiota and inflammation in patients with moderate-to-severe AV. Methods: A total of 28 patients were enrolled and received 30% SSA peels biweekly for 2 months. The Global Acne Grading System (GAGS) score, skin water content, transepidermal water loss (TEWL), pH, and sebum levels were assessed. Skin microbial samples and perilesional skin biopsies were obtained at the onset and 2 weeks after treatment completion. Samples were characterized using a high-throughput sequencing approach targeting a portion of the bacterial 16S ribosomal RNA gene. Results: After treatment, patients showed a significant improvement in their GAGS score and skin barrier indicators (P \ 0.05). The GAGS score was positively associated with both the sebum concentration (R = 0.3, P = 0.027) and pH (R = 0.39, P = 0.003). Increased expression of caveolin-1 and decreased expression of interleukin (IL)-1a, IL-6, IL-17, transforming growth factor beta, and toll-like receptor 2 were observed in the skin tissue after treatment. The richness and evenness of the cutaneous microbiome decreased after treatment and the Staphylococcus proportion decreased significantly (P \ 0.05), whereas the Propionibacterium proportion tended to decrease (P = 0.066). Conclusions: On the basis of analyses of the skin barrier and microbiota, we speculate that the 30% SSA peel may have a therapeutic effect in patients with moderate-to-severe AV by improving the skin microenvironment and modulating the skin microbiome, thus reducing local inflammation.

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30% supramolecular salicylic acid peels effectively treats acne vulgaris and reduces facial sebum

Cited by 12 publications

References 33 publications

Preparation and efficacy verification of three‐dimensional printed partitioned multi‐effect precision‐care gel facial mask

Preparation and efficacy verification of three‐dimensional printed partitioned multi‐effect precision‐care gel facial mask

0.5–5% Supramolecular Salicylic Acid Hydrogel is Safe for Long-Term Topical Application and Improves the Expression of Genes Related to Skin Barrier Homeostasis in Mice Models

Effect of 30% Supramolecular Salicylic Acid Peel on Skin Microbiota and Inflammation in Patients with Moderate-to-Severe Acne Vulgaris

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