307. Experiments on the synthesis of substances related to the sterols. Part II. A new general method for the synthesis of substituted cyclohexenones

Rapsōn, W. S.; Robinson, Robert

doi:10.1039/jr9350001285

Cited by 131 publications

(77 citation statements)

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“…New Zealanders both, Carman came from his post-graduate research at London University and Rapson from his association with Professor Sir Robert Robinson at the Dyson Perrins Laboratory in Oxford (Rapson & Robinson 1935). Carman was widely read, kindly, helpful to students, but by no means given to suffering fools gladly.…”

Section: The Chemistry Department University Of Cape Town (1918-1948)mentioning

confidence: 98%

A history of the Chemistry Department, University of Cape Town

Stephen¹

2005

Transactions of the Royal Society of South Africa

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includes material from its inception in 1876 until the closing years of the millennium preceding 1999. Several phases of growth are presented: first, as a one-man enterprise, Professor Paul Daniel Hahn introduced the teaching of Chemistry and fostered both pure and applied research; this developed with the founding of the University of Cape Town at the end of World War 1. A move into the new building at Groote Schuur followed, with a rapid expansion on many fronts after World War II. Apart from a brief interlude as a School comprising four separate Departments (1974)(1975)(1976)(1977)(1978)(1979)(1980)(1981)(1982)(1983)(1984)(1985)(1986)(1987)(1988), the Department of Chemistry continued to grow in terms of student numbers, courses offered, and productivity of its research groups, until the present time. The Department has occupied a large building, named after its first full-time professor, since 1972. Advances in performance, consequent on improved, computerised instrumentation and teaching techniques, are evident.

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Section: The Chemistry Department University Of Cape Town (1918-1948)mentioning

confidence: 98%

A history of the Chemistry Department, University of Cape Town

Stephen¹

2005

Transactions of the Royal Society of South Africa

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“…There are several examples of reported annulation reactions, including Robinson annulation, [73] Hauser annulation, [74] and Wichterle reaction. [75] Heteroaryl annulated carbazoles are always an attractive target in synthetic chemistry in view of their biological and pharmaceutical applications.…”

Section: Annulation Reactionsmentioning

confidence: 99%

Recent Developments in Indium Metal and Its Salts in Organic Synthesis

et al. 2010

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Indium and its salts have emerged as promising catalysts for effecting various functional group transformations in last two decades. There are a great number of reported reactions involving indium reagents; the versatility and the applicability of these reactions makes it a hot field to explore, and it attracts much interest from organic chemists. The development of indium reagents in C–C bond‐formation reactions, coupling reactions, asymmetric synthesis in the presence of chiral‐metal ligand complexes, etc. has made this field more attractive. Indium salts have pronounced Lewis acid character and are also attractive because of their moderate stability to water. Here we highlight developments in indium chemistry reported in the last eight years.

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“…To achieve the desired Robinson annulation [9,10] of the central six-membered ring of jiadifenolide, we modified a known, two-step method for merging the pulegone-derived β-keto ester 2 with methyl vinyl ketone; [11] this process, in which the Michael addition and ring-forming aldol condensation steps are performed in sequence, afforded bicyclic enone 6 , which was subsequently advanced to compound 7 by a base-mediated, deconjugative dimethylation. [12] After a protection of the keto group in the form of a dioxolane ketal, the carbomethoxyl group was reduced with diisobutylaluminum hydride and the resulting primary alcohol was oxidized to aldehyde 8 via the Swern method.…”

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An Enantiospecific Synthesis of Jiadifenolide

2014

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A Robinson annulation, van Leusen homologation, and a desymmetrizing C–H oxidation enabled an enantiospecific synthesis of the neurotrophic natural product jiadifenolide. From a pulegone-derived building block, a key propellane intermediate was constructed through the use of simple reagents in a highly diastereoselective fashion. A short series of oxidations of this tricylic framework allowed progression to the natural product.

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307. Experiments on the synthesis of substances related to the sterols. Part II. A new general method for the synthesis of substituted cyclohexenones

Cited by 131 publications

References 0 publications

A history of the Chemistry Department, University of Cape Town

A history of the Chemistry Department, University of Cape Town

Recent Developments in Indium Metal and Its Salts in Organic Synthesis

An Enantiospecific Synthesis of Jiadifenolide

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