308 Hemispheric Cerebral Oximetry Monitoring During Pediatric Seizure Activity Correlates to Seizure's Complexity and Acute Anticonvulsant Requirements in a Pediatric Emergency Department

Abstract

randomized and quasi-randomized controlled trials comparing glucocorticoids with any control (either placebo, adrenaline (epinephrine), an antihistamine, or any combination of these).Results: A total of 204 patients with biphasic anaphylaxis were identified with follow-up. All patients either experienced confirmed biphasic or protracted reactivity. Average time to onset of the second phase was 10.2 hours (CI: 2-38). Time to resolution of initial symptoms was significantly longer for biphasic reactors (112 vs 133 minutes; P ¼ .03). All biphasic and protracted anaphylactoid reactions received corticosteroids. Most importantly, patients who received steroid administration vs those who did not were equally as likely to experience protracted and biphasic reactions (P¼.04).Conclusions: Biphasic and protracted anaphlyaxis is a potential outcome for those experiencing anaphylactoid reactions. Prevention of this outcome is primarily unproven and based on observed data; there is no beneficence of steroid administration in the prevention of biphasic/protracted anaphlaxis. This neccessitates the need for further investigation into their efficacy.