31.6 Efficacy and Tolerability of Ziprasidone Use in Children and Adolescents: A Systematic Review and Meta-Analysis

Sareen, Aditya; Haza, Ingrid; Wadhwa, Abhishek; Soeung, Catherine; Peñuelas-Calvo, Inmaculada

doi:10.1016/j.jaac.2020.08.277

Cited by 1 publication

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“…Treatment methods for ADHD are diverse, with a strong emphasis on pharmacotherapy. Stimulants such as methylphenidate and amphetamines are the most widely used drugs, targeting neurotransmitter activity in the brain to relieve symptoms [1,2]. Nonstimulants, including atomoxetine and guanfacine, offer alternative mechanisms of action and are often considered when stimulant side effects are pronounced or in comorbidities, such as tic disorders.…”

Section: Introductionmentioning

confidence: 99%

Long-Term Safety and Efficacy of Stimulant vs. Non-Stimulant Medications in ADHD Treatment: A Comparative Meta-Analysis Over Two Years

2023

J Psychiatry Cogn Behav

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This systematic review and meta-analysis synthesize results from numerous studies to assess the long-term effects of ADHD medications, focusing on stimulants such as methylphenidate and amphetamine, and nonstimulant treatments. The review gathers data from Randomized Controlled Trials (RCTs) and observational studies with at least five years of follow-up, encompassing a substantial sample size from several international databases. The analysis confirms that pharmacotherapy for ADHD, which includes stimulants and non-stimulants, contributes to improved academic performance, social functioning, and reduces the risk of substance abuse and criminal behavior. While stimulants are highlighted for their effectiveness in symptom reduction and positive impact on social and academic outcomes, non-stimulants also demonstrate benefits, albeit with less consistency across studies. In addition, the research examines the comparative effectiveness and tolerability of these medications, noting that methylphenidate and amphetamine are generally the most effective, while clonidine, atomoxetine, and guanfacine are less so. Adverse effects, which vary by drug type, are recognized as important considerations, particularly in the context of comorbid tic disorders. The overall safety profile of these medications is considered acceptable, although stimulants are associated with a higher incidence of adverse events.

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Section: Introductionmentioning

confidence: 99%

Long-Term Safety and Efficacy of Stimulant vs. Non-Stimulant Medications in ADHD Treatment: A Comparative Meta-Analysis Over Two Years

2023

J Psychiatry Cogn Behav

View full text Add to dashboard Cite

show abstract

31.6 Efficacy and Tolerability of Ziprasidone Use in Children and Adolescents: A Systematic Review and Meta-Analysis

Cited by 1 publication

References 0 publications

Long-Term Safety and Efficacy of Stimulant vs. Non-Stimulant Medications in ADHD Treatment: A Comparative Meta-Analysis Over Two Years

Long-Term Safety and Efficacy of Stimulant vs. Non-Stimulant Medications in ADHD Treatment: A Comparative Meta-Analysis Over Two Years

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