318 Rare Presentation of Two Cases of West Nile Encephalitis in Kidney Transplant Patients

Torri, Deepti D.; Naber, Tamim H.; Yadav, Iti; Bhaskaran, Madhu; Molmenti, Ernesto P.; Mattana, Joseph; Sachdeva, Mala

doi:10.1053/j.ajkd.2011.02.321

American Journal of Kidney Diseases

2011

DOI: 10.1053/j.ajkd.2011.02.321

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318 Rare Presentation of Two Cases of West Nile Encephalitis in Kidney Transplant Patients

Deepti D. Torri

Tamim H. Naber

Iti Yadav

et al.

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A Scoping Review of Arthropod‐Borne Flavivirus Infections in Solid Organ Transplant Recipients

Im,

Altuame,

Gonzalez‐Bocco

et al. 2024

Transplant Infectious Dis

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Arthropod‐borne flaviviruses (ABFs), transmitted by mosquitoes or ticks, are increasing due to climate change and globalization. This scoping review examines the epidemiology, clinical characteristics, diagnostics, treatment, and outcomes of ABF infection in solid organ transplant recipients (SOTRs). A database search up to January 25, 2024, focused on ABFs such as West Nile virus (WNV), dengue virus (DENV), Japanese encephalitis virus (JEV), Powassan virus (POWV), yellow fever virus (YFV), and Zika virus (ZIKV), limited to SOTRs.We identified 173 WNV cases from 84 studies, with 28 donor‐derived infections (DDIs). Common clinical features included fever (78.5%), altered mental status (65.1%), and weakness or paralysis (45.6%). Treatment involved reducing immunosuppression (IS) in 93 cases, with intravenous immunoglobulin (IVIG), interferon alfa‐2b, and ribavirin used in 75 cases. Seven cases involved graft loss or rejection post‐infection. WNV infection had a 23.7% mortality rate, with severe neurological complications in 43.9%For DENV infection, 386 cases from 47 studies were identified, including 14 DDI cases. Symptoms included fever (85%), myalgias (56.4%), and headache or retro‐orbital pain (34.6%). Severe dengue occurred in 50 cases (13.0%). IVIG was administered in six cases. Reduction in IS was reported in 116 patients. DENV mortality rate was 4.9%.Additionally, 26 cases of less common ABFs such as JEV, POWV, YFV, and ZIKV were described.In summary, ABF infections among SOTRs are associated with higher morbidity and mortality compared to the general population, emphasizing the need for improved preventive strategies, timely diagnosis, and optimized management protocols.

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A Scoping Review of Arthropod‐Borne Flavivirus Infections in Solid Organ Transplant Recipients

Im,

Altuame,

Gonzalez‐Bocco

et al. 2024

Transplant Infectious Dis

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318 Rare Presentation of Two Cases of West Nile Encephalitis in Kidney Transplant Patients

Cited by 1 publication

References 0 publications

A Scoping Review of Arthropod‐Borne Flavivirus Infections in Solid Organ Transplant Recipients

A Scoping Review of Arthropod‐Borne Flavivirus Infections in Solid Organ Transplant Recipients

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