2009
DOI: 10.2478/s11658-008-0032-7
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31P MRS analysis of the phospholipid composition of the peripheral blood mononuclear cells (PBMC) and bone marrow mononuclear cells (BMMC) of patients with acute leukemia (AL)

Abstract: Abstract:The aim of this study was to evaluate the phospholipid concentration in acute leukemia (AL) blast cells from peripheral blood (PBMC) and bone marrow (BMMC). In vitro 31 P Nuclear Magnetic Resonance Spectroscopy ( 31 P MRS) was used. The integral intensities of the resonant peaks and the phospholipid concentrations in PBMC and BMMC were analyzed. Differences in the phospholipid concentrations in cells from myeloblastic or lymphoblastic lines were also evaluated. This investigation was carried out on ph… Show more

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Cited by 10 publications
(5 citation statements)
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“…The rather small increase in ζ upon addition of MP-1 to PCCol vesicles confirms the poor binding, and the flatness of the ζ potential curves suggests that <1 μM peptide is enough to hinder further binding. Those results are in accordance with the fact that cholesterol affects the fluidity and the dipole potential of phospholipid membranes, 40 inducing the ordering of the acyl chain region. 41 In this way, the attenuation of the porelike activity of PCCol bilayers can be correlated with the increase in the compressibility and bending modulii, hampering lytic activity.…”
Section: ■ Discussionsupporting
confidence: 90%
“…The rather small increase in ζ upon addition of MP-1 to PCCol vesicles confirms the poor binding, and the flatness of the ζ potential curves suggests that <1 μM peptide is enough to hinder further binding. Those results are in accordance with the fact that cholesterol affects the fluidity and the dipole potential of phospholipid membranes, 40 inducing the ordering of the acyl chain region. 41 In this way, the attenuation of the porelike activity of PCCol bilayers can be correlated with the increase in the compressibility and bending modulii, hampering lytic activity.…”
Section: ■ Discussionsupporting
confidence: 90%
“…Other anionic lipid species such as phosphatidylglycerol (PG), phosphatidic acid (PA), phosphatidylserine (PS), phosphatidylinositol (PI) and cardiolipin are also present at variable, and generally much higher, concentrations in native membranes 13 14 . Membrane lipid composition can vary under different physiological and pathological conditions 15 16 17 , and has been invoked causally in various diseases conditions 18 19 20 . However, progress in understanding the role of specific lipids in controlling of membrane protein function has been limited 21 because they cannot be readily manipulated in native membranes.…”
mentioning
confidence: 99%
“…These differences were reproduced in individual cancers with statistical significance reaching in BrC and CLL for respectively PC and PE levels. The previously published findings on the changes in PC and PE fractions are very diverse and sometimes controversial [39,40,41]. For example, substantial evidence suggests that PC levels are elevated during cancers, whereas significant decrease was noted in breast cancer cell lines [42].…”
Section: Discussionmentioning
confidence: 99%