31P MRS studies of exercising human muscle at high temporal resolution

Boska, Michael D.; Ja, Nelson; Sripathi, Naganand; Pipinos, Iraklis I.; Shepard, Alexander D.; Welch, K. M. A.

doi:10.1002/(sici)1522-2594(199906)41:6<1145::aid-mrm10>3.0.co;2-w

Cited by 19 publications

(28 citation statements)

References 16 publications

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“…TC ADP and Q max will reflect differences in muscle perfusion and any differences in reactive hyperemia induced by the preceding exercise. 17 The OxPhos parameter minimizes the effects of blood flow to the muscle following exercise on the initial PCr recovery rate. 15 -17 As discussed by Boska et al, the OxPhos parameter reflects muscle aerobic ATP production that is related to the number of mitochondria, the amount of stored substrates and O 2 in the muscle and blood at the beginning of the contraction.…”

Section: Discussionmentioning

confidence: 99%

“…15 -17 As discussed by Boska et al, the OxPhos parameter reflects muscle aerobic ATP production that is related to the number of mitochondria, the amount of stored substrates and O 2 in the muscle and blood at the beginning of the contraction. 17 Thus, OxPhos reflects both O 2 stores and mitochondrial function. 17 The TC ADP and Q max parameters reflect a combination of muscle perfusion and mitochondrial function.…”

Section: Discussionmentioning

confidence: 99%

“…17 Thus, OxPhos reflects both O 2 stores and mitochondrial function. 17 The TC ADP and Q max parameters reflect a combination of muscle perfusion and mitochondrial function. 17 When O 2 stores are depleted during an isometric exercise, it has been shown in severely hypoxemic pulmonary patients that the initial PCr recovery rate (OxPhos) is delayed even though mitochondrial function and perfusion are normal (ie normal TC ADP ).…”

Section: Discussionmentioning

confidence: 99%

“…17 The TC ADP and Q max parameters reflect a combination of muscle perfusion and mitochondrial function. 17 When O 2 stores are depleted during an isometric exercise, it has been shown in severely hypoxemic pulmonary patients that the initial PCr recovery rate (OxPhos) is delayed even though mitochondrial function and perfusion are normal (ie normal TC ADP ). 27 When the initial PCr recovery rate is delayed along with an increase in TC ADP and a decreased Q max then blood flow reductions and=or mitochondrial myopathy may be implicated.…”

Section: Discussionmentioning

confidence: 99%

“…20,21,25 The net forward ATP production rates from the creatine kinase reaction (CK), oxidative phosphorylation (OxPhos) and anaerobic glycolysis (AnGly) were calculated using the methods of Boska 15,17 and Newcomer et al 16 Additionally, mitochondrial function was estimated from the recovery time constant of ADP (TC ADP ) 18,19 and from Kemp et al's V PCr and Q max . 17,22 Historically, the quantity V PCr was used when spectra are collected with time resolution too slow to directly measure the initial PCr recovery slope. V PCr was intended to reflect initial PCr recovery rate, the same quantity as the OxPhos parameter discussed previously.…”

Section: Experimental Protocolmentioning

confidence: 99%

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Skeletal muscle metabolism in overweight and post-overweight women: an isometric exercise study using 31P magnetic resonance spectroscopy

et al. 2001

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OBJECTIVE:To investigate whether skeletal muscle anaerobic metabolism, oxidative metabolism or metabolic economy during controlled sub-maximal and near-maximal exercises is altered in overweight women after diet-induced weight reduction, and whether these parameters are different between normal-weight, obesity-prone and normal-weight obesity-resistant women with similar physical fitness levels. DESIGN: A prospective weight loss study of overweight women and their comparison with never overweight controls. SUBJECTS: Thirty overweight, nondiabetic, premenopausal women and 28 never overweight controls were included in this analysis. All were participating in a longitudinal investigation of the role of energy metabolism in the etiology of obesity. The overweight women were recruited specifically to have a positive family history of obesity and have a body mass index (BMI) between 27 and 30 kg=m 2 and were studied in the overweight state and after reduction to a normal weight. The neveroverweight controls were recruited specifically to have no personal and family history of obesity and were group matched with the weight-reduced post-overweight subjects in terms of premenopausal status, age, BMI, race and sedentary lifestyle. MEASUREMENTS: All testing was performed following one month of weight maintenance and during the follicular phase of the menstrual cycle. Hydrostatic weighing was performed to measure body composition and a whole-body maximal oxygen uptake (VO 2max ) test was done to measure aerobic fitness. 31 P MRS was used to determine ATP production from oxidative phosphorylation (OxPhos), 'anaerobic' glycolysis (AnGly), and creatine kinase (CK), as well as muscle metabolic economy. The time constant of ADP (TC ADP ), V PCr (ie the initial rate of PCr resynthesis following exercise), and Q max (ie the apparent maximal oxidative ATP production rate) were also calculated as additional markers of mitochondrial function. RESULTS: Diet-induced weight loss did not have any effects on the anaerobic metabolism markers (AnGly and CK). The aerobic metabolism markers calculated from the initial recovery data (OxPhos and V PCr ) were unaffected by diet-induced weight loss. However, diet-induced weight loss resulted in improvements in the TC ADP and Q max in the post-overweight state as compared to their overweight state. There were no differences in any of the anaerobic (AnGly and CK) or oxidative metabolism markers (OxPhos, V PCr , Q max and TC ADP ) between the post-overweight and control groups. CONCLUSIONS: Once the overweight women were reduced to a normal-weight state, their skeletal muscle energy metabolism and economy was similar to the never overweight control women. In overweight women, oxidative metabolism or mitochondrial function may be limited by blood flow to the muscle following the cessation of exercise.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Experimental Protocolmentioning

confidence: 99%

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Skeletal muscle metabolism in overweight and post-overweight women: an isometric exercise study using 31P magnetic resonance spectroscopy

et al. 2001

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Insights into muscle diseases gained by phosphorus magnetic resonance spectroscopy

2000

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Phosphorus magnetic resonance spectroscopy (P‐MRS) has now been used in the investigation of muscle energy metabolism in health and disease for over 15 years. The present review describes the basics of the metabolic observations made by P‐MRS including the assumptions and problems associated with the use of this technique. Extramuscular factors, which may affect the P‐MRS results, are detailed. The important P‐MRS observations in patients with mitochondrial myopathies, including the monitoring of experimental therapies, are emphasized. The findings in other metabolic myopathies (those associated with glycolytic defects or endocrine disturbances) and in the destructive myopathies (the dystrophies and the inflammatory myopathies) are also described. Observations made in normal and abnormal fatigue, fibromyalgia, and malignant hyperthermia are considered. Finally, a summary of the possible diagnostic use of P‐MRS in exercise intolerance is provided. © 2000 John Wiley & Sons, Inc. Muscle Nerve 23: 1316–1334, 2000.

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Transcatheter closure of a traumatic VSD in an adult requiring an ASD occluder device

Suh

Kern

2009

Cathet Cardio Intervent

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Traumatic ventricular septal defects (VSD) can occur after blunt or penetrating chest trauma or cardiac procedures. There are few publications reporting the safety and efficacy of transcatheter closure of traumatic VSDs. We report a case of a large VSD resulting from penetrating chest trauma that was not repaired at the initial surgical procedure on the disrupted right ventricle. Because of the late identification of the VSD postoperatively, transcatheter closure after the original surgical procedure was recommended and performed requiring an Amplatzer atrial septal defect occluder device because of defect size and configuration. This case describes the technique and postprocedure imaging leading to a cautionary note regarding VSD closure device techniques.

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31P MRS studies of exercising human muscle at high temporal resolution

Cited by 19 publications

References 16 publications

Skeletal muscle metabolism in overweight and post-overweight women: an isometric exercise study using 31P magnetic resonance spectroscopy

Skeletal muscle metabolism in overweight and post-overweight women: an isometric exercise study using 31P magnetic resonance spectroscopy

Insights into muscle diseases gained by phosphorus magnetic resonance spectroscopy

Transcatheter closure of a traumatic VSD in an adult requiring an ASD occluder device

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