31P NMR Studies of Human Skin using a Modified Zig-Zag Surface Coil

Skin phosphocreatine

“…I could not agree more with the conclusion of this elegant study by Schlattner and Walliman: ‘We detected the presence of functional PCR/CPK system in many metabolically very active cell types of skin, especially in epidermis and hair follicles.’ Finally, Bohning and his radiology colleagues at Medical University of South Carolina, utilizing the two‐power depth resolution 31 P MRS technique, which completely eliminates underlying skeletal muscle contamination, confirmed spectrascopically the presence of PCR in human skin (11, 12). Cowie et al (18) confirmed Bohning 31 P MRS data using a modified zig–zag surface coil. Finally, Smith et al performed both 31 P MRS and chromatographic evaluation of normal and dialetic skin, confirming not just the presence of PCR in the skin but also an excellent correlation between MRS and chromatographic data, stating that their data ‘produced a value quite similar to that reported by Zemtsov et al’ (19).…”

Age‐dependent response of energy metabolism of human skin to UVA exposure: anin vivostudy by31P nuclear magnetic resonance spectroscopy

“…Moreover, the examination time should be kept as short as possible to avoid disturbances of the metabolism of the skin caused by the contact with the surface coil and to preserve the comfort of the subjects (but long enough to be‐non‐detrimental to the signal‐to‐noise ratio). Several teams have proposed solutions to overcome these difficulties (19–22). We have used a slotted crossover surface coil specifically designed to minimize depth sensitivity while maintaining high probe sensitivity over the surface of the skin to achieve good SNR (18, 23).…”

In Vivo Measurement of Phosphorous Markers of Disease

“…Since the advent of larger bore spectrometers, human studies in healthy individuals have been carried out showing the usefulness of in vivo 31 P MRS to study normal muscle [23][24][25][26][27][28][29][30][31][32][33]4,[35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53], liver [54,55], kidney [56], brain [4,7,[57][58][59][60][61][62], testes [63], spleen [64], skin [65,66], heart [67,68], breast [69], uterus [70], and blood…”