329: Excess complement activation is associated with adverse outcomes in women with hypertensive disorders of pregnancy

Abstract

0.36 AE0.22-fold, respectively; p¼0.0003). VE obtained from normal pregnant women also showed a down-regulation of sFlt1 expression in response to cAMP (0.56 AE0.2 fold). However, the VE from PE placenta showed an upregulation of sFlt1 (1.82 AE0.8 fold, p¼0.0001). CONCLUSION: While cAMP-mediated regulation of sFlt1 is similar in the decidua of normal vs PE placentas, there are marked differences in this regulation in the villous cells from these 2 groups of patients. The increased expression of sFlt1 induced by cAMP in VE from PE patients suggests that placentas of women with PE may have alterations in cAMP-mediated regulation of this gene, leading to an overexpression and secretion of sFlt1.