330 Phosphodiesterase Inhibitors Attenuate the Contractile Activity of Human Seminal Vesicle Smooth Muscle -an in Vitro Study

The properties of phosphodiesterase 11A4 GAF domains are regulated by modifications in its N‐terminal domain

“…In addition, it is speculated that PDE11 plays a role in the pathology of major depressive disorder [23] and the development of endocrinal tumours [24]. Furthermore, hPDE11 presumably plays a role in various urological diseases such as benign prostatic syndrome, erectile dysfunction and premature ejaculation [25,26]. In agreement with the expression of PDE5 and PDE11 in the transitional zone of the prostate, these PDE isoforms might also have a role in regulating the proliferation of glandular epithelial tissue; PDE5 and PDE11 inhibitors might, therefore, prevent the malignant transformation of prostatic cells.…”