34 Relationship Between Intra-erythrocyte Sodium Content and Cation Transport in Hypertension, Hyperthyroidism, Pregnancy and Hypokalaemia

Gless, K.-H.; tterlin, U S; Schaz, K.; Gross, Paul M.; Tž, Vrkić; Hünstein, W.

doi:10.1097/00004872-198402000-00049

Cited by 8 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results for healthy subjects are consistent with those of other centres (e.g. Mfinchen [6], Mainz [21], Heidelberg [10], Leuven [12], or Chicago [2]). Different methods, however, are used to measure the sodium influx and the Na+/K + pump activity.…”

Section: Discussionsupporting

confidence: 92%

Erythrocyte sodium content and transport in borderline and mild hypertension

Engelhardt

Scholze

1988

Klin Wochenschr

View full text Add to dashboard Cite

Sodium content and transport of red blood cells were examined in 98 male blood donors. Regarding their blood pressure they were classified into the following groups: (a) 57 normotensives, (RR less than 140/90 mm Hg); (b) 24 borderline hypertensives (140/90 less than or equal to RR less than 160/95 mm Hg); and (c) 17 hypertensives (RR greater than 160/100 mm Hg). Compared with the normotensives the borderline hypertensives have significantly reduced red cell sodium content. The ouabain-resistant net Na+ uptake and the relative Na+ uptake, as a measure of the Na+/K+ pump, were significantly increased. With rising blood pressures the measured values turn to normal, so that no difference exists between the normotensive and hypertensive groups. It is supposed that in the initial or even prehypertensive state a considerable enhancement of the pump activity occurs, simultaneously accompanied by less marked increases in sodium influx, leading to a reduced intracellular sodium content. In the course of hypertension, possibly caused by the formation of a pump inhibitor, the sodium content of red cells turns to normal or supernormal values.

show abstract

Section: Discussionsupporting

confidence: 92%

Erythrocyte sodium content and transport in borderline and mild hypertension

Engelhardt

Scholze

1988

Klin Wochenschr

View full text Add to dashboard Cite

show abstract

“…In normal pregnancy, it was previously reported that the number of Na,K-ATPase pump units increased in the third trimester compared with that in control subjects [1 9-21 ], whereas the pump function was reported to be increased [21][22][23] or unchanged [20,24]. In the present study, increases in both the number and function of the pump were observed in normal pregnant women.…”

Section: Discussionsupporting

confidence: 53%

Measurement of Erythrocyte Na,K-ATPase Activity in Normal Pregnant Women.

et al. 1993

View full text Add to dashboard Cite

Abstract. To investigate the peripheral metabolic status during normal pregnancy, we measured the number of erythrocyte Na,K-ATPase units as well as the cation transport activity of the pump from 32 normal pregnant women and 12 normal controls. The number of pump units determined by maximal ouabain binding to erythrocyte in normal pregnancy was significantly higher than that in normal controls (mean±SEM: 0.52±0.03 vs. 0.39±0.04 pmol/1O9RBC, P

show abstract

“…This observation is in accordance with previous findings indicating that erythrocyte ion transport is altered in hyperthyroidism. Changes in sodium metabolism in hyperthyroidism have been discussed extensively by several groups [22][23][24][25]. Although their clinical significance is not known, they indicate pathophysiological responses to high plasma thyroid levels.…”

Section: Discussionmentioning

confidence: 99%