343: Deciphering the role of ubiquitin specific peptidase 15 (USP15) in human glioblastoma

Oikonomaki, Maria; Hegi, Monika E.

doi:10.1016/s0959-8049(14)50305-x

European Journal of Cancer

2014

DOI: 10.1016/s0959-8049(14)50305-x

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343: Deciphering the role of ubiquitin specific peptidase 15 (USP15) in human glioblastoma

Maria Oikonomaki¹,

Monika E. Hegi²

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What deubiquitinating enzymes, oncogenes, and tumor suppressors actually do: Are current assumptions supported by patient outcomes?

Gregoire‐Mitha

Gray

2021

BioEssays

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Context can determine whether a given gene acts as an oncogene or a tumor suppressor. Deubiquitinating enzymes (DUBs) regulate the stability of many components of the pathways dictating cell fate so it would be expected that alterations in the levels or activity of these enzymes may have oncogenic or tumor suppressive consequences. In the current review we survey publications reporting that genes encoding DUBs are oncogenes or tumor suppressors. For many DUBs both claims have been made. For such “double agents,” the effects of gain or loss of function will depend on the overall status of a complex of molecular signaling networks subject to extensive crosstalk. As the TGF‐β paradox makes clear context is critical in cell fate decisions, and the disconnect between experimental findings and patient survival outcomes can in part be attributed to disparities between culture conditions and the microenvironment in vivo. Convincing claims for oncogene or tumor suppressor roles require the documentation of gene alterations in patient samples; survival curves are alone inadequate.

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What deubiquitinating enzymes, oncogenes, and tumor suppressors actually do: Are current assumptions supported by patient outcomes?

Gregoire‐Mitha

Gray

2021

BioEssays

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343: Deciphering the role of ubiquitin specific peptidase 15 (USP15) in human glioblastoma

Cited by 1 publication

References 0 publications

What deubiquitinating enzymes, oncogenes, and tumor suppressors actually do: Are current assumptions supported by patient outcomes?

What deubiquitinating enzymes, oncogenes, and tumor suppressors actually do: Are current assumptions supported by patient outcomes?

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