35: Ketorolac‐Induced Status Asthmaticus Following Endoscopic Sinus Surgery in a Samter's Triad Patient

Abstract

Functional endoscopic sinus surgery is frequently performed in patients with chronic sinusitis in association with Samter's triad. We present a case report of ketorolac-induced status asthmaticus in a postoperative patients with Samter's triad. Ketorolac (Toradol) is a nonsteroidal, antiinflammatory medication increasingly used by anesthesiologists and nurse anesthetists intravenously during surgical procedures and in postoperative pain management. Because many allied health professionals including anesthesia staff, nursing staff, and house officers may not be familiar with this triad and its potentially life-threatening adverse reaction to nonsteroidal antiinflammatory drugs, we present a discussion of the potential risk of severe bronchospasm in Samter's triad patients if nonsteroidal, antiinflammatory drugs such as Toradol are administered.

Ketorolac tromethamine associated with diffuse pulmonary haemorrhage: high-resolution CT findings

“…KT is known as a potential cause of bleeding and is contraindicated in patients with haemorrhagic diathesis, incomplete haemostasis, previous gastrointestinal bleeding, suspected or confirmed cerebrovascular bleeding, or as pre-operative or prophylactic intraoperative treatment for pain relief. The drug can also trigger severe bronchospasm or anaphylactic reaction [6]. Non-steroidal anti-inflammatory treatment can cause nasal epistaxis [7] but, to our knowledge, there are no previous published reports on spontaneous pulmonary haemorrhage as a consequence of KT use.…”