356: PP13, PAPP-A, first-trimester uterine-artery Doppler measurements, and maternal characteristics in the prediction of small for gestational age fetuses

Meints, Laura; Cahill, Alison G.; Huster, Kristina M.; Odibo, Linda; McVean, Dominique; Odibo, Anthony O.

doi:10.1016/j.ajog.2011.10.374

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In all, 162 studies were excluded, the main reasons being the lack of data to construct 2 × 2 tables (43%) and not being a test accuracy study (25%). Fifty‐three studies including 39 974 women, evaluating a total of 37 novel biomarkers, met the inclusion criteria . Box lists novel biomarkers for predicting IUGR that were identified in this review.…”

Section: Resultsmentioning

confidence: 99%

“…Three studies provided data on a disintegrin and metalloprotease (ADAM)‐12, four on placental protein 13 (PP‐13), three on pregnancy‐specific β‐1‐glycoprotein, two on hepatocyte growth factor, and one each on insulin‐like growth factor binding proteins 1 and 3, activin A, placental growth hormone and annexin A5 . ADAM‐12 and PP‐13 were assessed at <20 weeks of gestation in all included studies.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Novel biomarkers for predicting intrauterine growth restriction: a systematic review and meta‐analysis

Conde-Agudelo

Papageorghiou

Kennedy

et al. 2013

BJOG

130

101

View full text Add to dashboard Cite

Background Several biomarkers for predicting intrauterine growth restriction (IUGR) have been proposed in recent years. However, the predictive performance of these biomarkers has not been systematically evaluated.Objective To determine the predictive accuracy of novel biomarkers for IUGR in women with singleton gestations.Search strategy Electronic databases, reference list checking and conference proceedings.Selection criteria Observational studies that evaluated the accuracy of novel biomarkers proposed for predicting IUGR.Data collection and analysis Data were extracted on characteristics, quality and predictive accuracy from each study to construct 2 9 2 tables. Summary receiver operating characteristic curves, sensitivities, specificities and likelihood ratios (LRs) were generated.Main results A total of 53 studies, including 39 974 women and evaluating 37 novel biomarkers, fulfilled the inclusion criteria. Overall, the predictive accuracy of angiogenic factors for IUGR was minimal (median pooled positive and negative LRs of 1.7, range 1.0-19.8; and 0.8, range 0.0-1.0, respectively). Two small case-control studies reported high predictive values for placental growth factor and angiopoietin-2 only when IUGR was defined as birthweight centile with clinical or pathological evidence of fetal growth restriction. Biomarkers related to endothelial function/ oxidative stress, placental protein/hormone, and others such as serum levels of vitamin D, urinary albumin : creatinine ratio, thyroid function tests and metabolomic profile had low predictive accuracy.Conclusions None of the novel biomarkers evaluated in this review are sufficiently accurate to recommend their use as predictors of IUGR in routine clinical practice. However, the use of biomarkers in combination with biophysical parameters and maternal characteristics could be more useful and merits further research.

show abstract

Section: Resultsmentioning

confidence: 99%