Biomedical research is often a collaborative effort involving anthropologists, epidemiologists, and clinically based medical researchers and care givers. In multidisciplinary, multi‐institutional research projects barriers to successful research collaboration multiply easily, in part because different disciplines conceptualize study design and other research issues differently. Institutional requirements for research (human subjects' approval, for example) also differ. When research activities are performed by clinical personnel at clinical institutions, research must give way to care giving. Strategies to overcome these and other problems are based on the professionalism of clinical and medical research staff and involve awareness of each host institution's reward systems and hierarchies. Practical, concrete solutions to these problems exist and are described.