371P Effect of oral silymarin administration on prevention of radiotherapy induced mucositis: A randomized, double-blinded, placebo-controlled clinical trial

Hosseini, S.; Elyasi, S.; Moghadam, M.R. Niazi; Aledavood, S.A.; Karimi, G.

doi:10.1093/annonc/mdw587.013

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“…This review comprises about the findings of recent reports, which can be utilize for designing novel targeted delivery system for some serious physiological co-morbid conditions, like cardiovascular, cancer and other metabolic disorders, or those conditions still difficult to handle with conventional therapeutic approaches. Patients with Non-alcoholic Steatohepatitis 700 mg daily three times for 48 weeks Oral Safe and well tolerated [72] Patient with acute hepatitis 140 mg daily for 4 weeks Oral None [73] Patient with head and neck cancer 420 mg daily three times for 6 weeks Oral None [74] Patients with breast cancer 1 % gel daily for 5 weeks Topical None [75] Patients with gastrointestinal cancer 1 % gel twice daily for 9 weeks Topical None [76] ▶table 4 Available Marketed formulations of silybin and their potential uses. This document was downloaded for personal use only.…”

Section: Discussionmentioning

confidence: 99%

Recapitulation of Evidence of Phytochemical, Pharmacokinetic and Biomedical Application of Silybin

et al. 2021

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Silymarin is a standardized extract obtained from seeds of Silybum marianum (SM) belonging to the family Asteraceae. It is a flavonolignan complex and consists of various compounds like silybin A silybin B, isosilybin A, isosilybin B, silydianin, silychristin and isosilychristin. Silybin is the major active component present in 60–70% of the silymarin extract. It has been used traditionally for the treatment of various liver disorders like cirrhosis, jaundice, and hepatitis. Silymarin possesses antioxidant and anti-inflammatory properties and is responsible for its antitumor activity. Other than hepatoprotective effect SM also possesses renoprotective, anti-diabetic, neuroprotective, hypolipidemic, anti-atherosclerosis and cardioprotective effects. Rather antimicrobial property of silymarin was observed against specific microbes, fungi, and viruses. This manuscript covered recent preclinical and clinical evidence of specific components silybin, responsible for its efficacy and about clinical studies has been conducted so far, which proven it’s safety and offers mild effect like nausea, diarrhea and bloating. This review specifically focused on recent updates on its active components therapeutic applications against complicated ailments not covered in earlier reports.

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