379 Early Results from the SoundMate Study. Acoustic Analysis of a Thromboembolic Event in a Patient Treated with HeartMate II™, Mechanical Circulatory Support

Hübbert, Laila; Jorde, Ulrich P.; Peterzén, Bengt; Granfeldt, Hans; Kornhall, Björn; Morrison, Kerry A.; Ahn, Henrik Casimir

doi:10.1016/j.healun.2012.01.388

Cited by 7 publications

(10 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The development of a pump thrombosis is difficult to detect, and an embolic event may be the first symptom suffered by the patient. Our clinical finding of an altering sound from the left ventricular assist device (LVAD) HeartMate II (Thoratec Corporation, Inc., Pleasanton, CA, USA) (HMII), heard through a regular stethoscope in recipients before the occurrence of a thromboembolic event, has resulted in the ongoing SoundMate study, where patients with an HMII perform daily acoustic recordings at home and transmit them to the study center via a smartphone 4 . A continuous flow MCS generates a typical sound that is easily registered by routine auscultation.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Acoustic Analysis of a Mechanical Circulatory Support

et al. 2013

View full text Add to dashboard Cite

Mechanical circulatory support technology is continually improving. However, adverse complications do occur with devastating consequences, for example, pump thrombosis that may develop in several parts of the pump system. The aim of this study was to design an experimental clot/thrombosis model to register and analyze acoustic signals from the left ventricular assist device (LVAD) HeartMate II (HMII) (Thoratec Corporation, Inc., Pleasanton, CA, USA) and detect changes in sound signals correlating to clots in the inflow, outflow, and pump housing. Using modern telecom techniques, it was possible to register and analyze the HMII pump-specific acoustic fingerprint in an experimental model of LVAD support using a mock loop. Increase in pump speed significantly (P < 0.005) changed the acoustic fingerprint at certain frequency (0–23 000 Hz) intervals (regions: R1–3 and peaks: P1,3–4). When the ball valves connected to the tubing were narrowed sequentially by ∼50% of the inner diameter (to mimic clot in the out- and inflow tubing), the frequency spectrum changed significantly (P < 0.005) in P1 and P2 and R1 when the outflow tubing was narrowed. This change was not seen to the same extent when the lumen of the ball valve connected to the inflow tube was narrowed by ∼50%. More significant (P < 0.005) acoustic changes were detected in P1 and P2 and R1 and R3, with the largest dB figs. in the lower frequency ranges in R1 and P2, when artificial clots and blood clots passed through the pump system. At higher frequencies, a significant change in dB figs. in R3 and P4 was detected when clots passed through the pump system. Acoustic monitoring of pump sounds may become a valuable tool in LVAD surveillance.

show abstract

mentioning

confidence: 99%

“…To our knowledge, there is no article published, apart from abstracts, on acoustic data from continuous flow devices 4 , 9 .…”

mentioning

confidence: 99%

Acoustic Analysis of a Mechanical Circulatory Support

et al. 2013

View full text Add to dashboard Cite

show abstract

“…These recordings were made with an iPhone, recorded at home and transferred electronically for distance monitoring. 259 Further studies on HVAD in small settings showed that alteration in peak amplitude was associated with outflow occlusion and changes in MAP. 260 Acoustic spectral analysis of HVAD was analyzed in 105 patients of whom 8 had signs of pump thrombosis which also was confirmed after surgical pump exchange.…”

Section: Sound Analysis Of Lvadmentioning

confidence: 99%

Acoustic and afterload evaluation of left ventricular assist devices

Sundbom

2019

Linköping University Medical Dissertations

View full text Add to dashboard Cite

Pulse width modulation RAAS Renin-Angiotensin Aldosterone system ROS Reactive oxygen species RPM Revolutions per minute RV Right ventricular TGF-β Transforming growth factor-β vWf Von Willebrand factor HF Unable to carry on any physical activity without symptoms of HF, or symptoms of heart failure at rest Hypertension Arrythmias Tachyarrythmias Atrial and ventricular arrythmias Bradyarrythmias Sinus node dysfunction, conduction disorders Valve disease Congentinal Atrial and ventricular septum defects Acquired Aortic, mitral, pulmonary and tricuspid valve disease High output Anemia, pregnancy, thyreotoxicosis, sepsis Volume overload Renal failure, iatrogen volume overload Others Pericardial Constrictive pericarditis, pericardial effusion Endomyocardial

show abstract

“…In recent years, analysis of LVAD sound recordings emerged as a means to evaluate pump function and pump thrombosis. [2][3][4][5][6][7][8][9] In 2007, Slaughter et al 2 reported that acoustics analysis can detect device end-of-life in the HeartMate XVE…”

Section: Introductionmentioning

confidence: 99%

Sound analysis of a left ventricular assist device: A technical evaluation of iOS devices

Sundbom¹,

Roth

Granfeldt

et al. 2018

Int J Artif Organs

View full text Add to dashboard Cite

Introduction: The use of left ventricular assist device (LVAD) has grown rapidly. Adverse events do continue to occur. In recent years, analysis of LVAD sound recordings emerged as a means to monitor pump function and detect pump thrombosis. The aim of this study was to characterize the sounds from HeartMate II and to evaluate the use of handheld iOS devices for sound recordings. Method: Signal analysis of LVAD sound recordings, with dedicated recording equipment and iOS devices, was performed. Two LVADs running in mock loop circuits were compared to an implanted LVAD. Spectral analysis and parametric signal models were explored to quantify the sound and potentially detect changes in it. Results: The sound recordings of two LVADs in individual mock loop circuits and a third one implanted in a patient appeared to be similar. Qualitatively, sound characteristics were preserved following changes in pump speed. Recordings using dedicated equipment showed that HeartMate II sound comprises low-frequency components corresponding to pump impeller rotation, as well as high-frequency components due to a pulse width modulation of the electric power to the pump. These different signal components interact and result in a complicated frequency spectrum. The iPhone and iPod recordings could not reproduce the sounds as well as the dedicated equipment. In particular, lower frequencies were affected by outside disturbances. Discussion: This article outlines a systematic approach to LVAD sound analysis using signal processing methods to quantify and potentially detect changes, and describes some of the challenges, for example, with the use of inexpensive recording devices.

show abstract

379 Early Results from the SoundMate Study. Acoustic Analysis of a Thromboembolic Event in a Patient Treated with HeartMate II™, Mechanical Circulatory Support

Cited by 7 publications

References 0 publications

Acoustic Analysis of a Mechanical Circulatory Support

Acoustic Analysis of a Mechanical Circulatory Support

Acoustic and afterload evaluation of left ventricular assist devices

Sound analysis of a left ventricular assist device: A technical evaluation of iOS devices

Contact Info

Product

Resources

About