380P Prospective randomized trial of standard antiemetic therapy with yoga versus standard antiemetic therapy alone for highly emetogenic chemotherapy induced nausea and vomiting in South Asian population

Abstract

Aim/Background: Chemotherapy induced nausea and vomiting is one of the most distressing side effects of highly emetogenic chemotherapy regimens. There have been continuous efforts in the direction to control Chemotherapy induced nausea and vomiting (CINV) by many investigators.Methods: Randomly selected patients were those receiving highly emetogenic chemotherapy regimen grouped into yoga and standard antiemetic therapy (n = 50) just prior to receiving chemotherapy and continued for the following days and other group (n = 50) received only the standard antiemetic agent. Both the groups were assessed, followed for acute and delayed onset of chemotherapy induced and anticipatory nausea and vomiting using RTOG grading for the same. We also assessed the Quality of Life of the patient using the FACT-G questionnaire. Results: The median age group of the patients was 51 years with M:F 2:1, ECOG performance status 0/1,2 38% v/s 62%. In Yoga arm insignificant reduction in chemotherapy induced nausea (90% vs 78%, p = .35) and but significant reduction in vomiting (42% vs 22%, p =