394 Ex Vivo Perfusion Worsened Lung Injuries Induced by Gastric Acid Aspiration in Pigs

Khalifé-Hocquemiller, Theresa; Sage, Édouard; Dorfmüller, Peter; Eddahibi, Saadia; Fadel, Élie

doi:10.1016/j.healun.2011.01.402

Cited by 7 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Currently, lungs injured by aspiration of gastric content are not considered for transplant. Conventional EVLP seems ineffective in improving lungs with an ab ingestis damage (27), however direct instillation of exogenous surfactant via a bronchoscope (28) during EVLP showed promising results.…”

Section: Evlpmentioning

confidence: 99%

Lung transplantation, ex-vivo reconditioning and regeneration: state of the art and perspectives

Rosso¹,

Zanella²,

Righi³

et al. 2018

J. Thorac. Dis.

View full text Add to dashboard Cite

Lung transplantation is the only therapeutic option for end-stage pulmonary failure. Nevertheless, the shortage of donor pool available for transplantation does not allow to satisfy the requests, thus the mortality on the waiting list remains high. One of the tools to overcome the donor pool shortage is the use of lung perfusion (EVLP) to preserve, evaluate and recondition selected lung grafts not otherwise suitable for transplantation. EVLP is nowadays a clinical reality and have several destinations of use. After a narrative review of the literature and looking at our experience we can assume that one of the chances to improve the outcome of lung transplantation and to overcome the donor pool shortage could be the tissue regeneration of the graft during EVLP and the immunomodulation of the recipient. Both these strategies are performed using mesenchymal stem cells (MSC). The results of the models of lung perfusion with MSC-based cell therapy open the way to a new innovative approach that further increases the potential for using of the lung perfusion platform.

show abstract

Section: Evlpmentioning

confidence: 99%

Lung transplantation, ex-vivo reconditioning and regeneration: state of the art and perspectives

Rosso¹,

Zanella²,

Righi³

et al. 2018

J. Thorac. Dis.

View full text Add to dashboard Cite

show abstract

“…Altogether, cross-circulation EVLP enabled significant cellular regeneration and functional restoration of the blood-air barrier that correlated with improved respiratory performance of ex vivo lungs. Furthermore, as previous attempts to recover lungs injured by gastric aspiration using isolated EVLP have been unsuccessful, 11 gastric aspiration remains a contraindication for standard EVLP practice. 12 Our studies confirmed that allogeneic cross-circulation EVLP can regenerate severely injured lungs and thus could potentially be used to expand ex vivo donor organ recovery.…”

Section: New Application Of An Old Conceptmentioning

confidence: 99%

Xenogeneic support for the recovery of human donor organs

O’Neill

Guenthart

Hozain

et al. 2022

The Journal of Thoracic and Cardiovascular Surgery

View full text Add to dashboard Cite

“…In further studies, the authors also showed (49, 51) impaired oxygenation and increased inflammatory response to gastric acid injury. In addition, EVLP can be used to detect features of gastric aspiration in the donor lung and may predict early graft dysfunction (47). Sahara et al (52) have used human blood perfusion in a GalT-KO (galactosyl transferase gene knockout) porcine versus wild-type.…”

Section: Evlp As a Research Toolmentioning

confidence: 99%

Ex Vivo Lung Perfusion

Roman

Nair²,

Tsui³

et al. 2013

Transplantation

View full text Add to dashboard Cite

There is a critical mismatch between the number of donor lungs available and the demand for lungs for transplantation. This has created unacceptably high waiting-list mortality for lung transplant recipients. Currently (2012) in the United Kingdom, there are 216 patients on the lung transplant waiting list and 17 on heart and lung transplant list. The waiting times for suitable lungs average 412 days, with an increasing mortality and morbidity among the patients on the lung transplant list. Ex vivo lung perfusion (EVLP) has emerged as a technique for the assessment, resuscitation, and potential repair of suboptimal donor lungs. This is a rapidly developing field with significant clinical implications. In this review article, we critically appraise the background developments that have led to our current clinical practice. In particular, we focus on the human and animal experience, the different perfusion-ventilation strategies, and the impact of different perfusates and leukocyte filters. Finally, we examine EVLP as a potential research tool. This will provide insight into EVLP and its future development in the field of clinical lung transplantation.

show abstract

394 Ex Vivo Perfusion Worsened Lung Injuries Induced by Gastric Acid Aspiration in Pigs

Cited by 7 publications

References 0 publications

Lung transplantation, ex-vivo reconditioning and regeneration: state of the art and perspectives

Lung transplantation, ex-vivo reconditioning and regeneration: state of the art and perspectives

Xenogeneic support for the recovery of human donor organs

Ex Vivo Lung Perfusion

Contact Info

Product

Resources

About