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Reaction of 2-aminothiophenol with acrylic acid and conversion of the resultant adducts

“…1 ArH); 6.58 (1H, t, J = 7.5, ArH); 5.51 (1H, s, NH); 3.38 (2H, t, J = 6.8, NCH 2 ); 2.84 (2H, t, J = 6.8, SCH 2 ); 2.55 (2H, t, J = 6.8, COCH 2 ); 2.40 (2H, t, J = 6.8, COCH 2 ). 13 C NMR spectrum, δ, ppm: 173.8 (C (12) ); 172.78 (C (11) ); 148.55 (C (2) ); 135.77 (C (3) ); 130.12 (C (4) ); 116.24 (C (5) ); 116.05 (C (6) ); 109.96 (C (1) ); 38.72 (C (7) ); 33.77 (C (10) ); 33.36 (C (8) ); 29.04 (C (9) ). Mass spectrum, m/z (I rel , % .37 (2H, t, J = 6.6, NCH 2 ); 2.84 (2H, t, J = 6.6, COCH 2 ); 2.55 (2H, t, J = 7.2, COCH 2 ); 2.40 (2H, t, J = 7.2, SCH 2 ).…”

“…1 H NMR spectrum, δ, ppm (J, Hz): 11.36 (1H, s, NH); 7.55 (1H, d, J = 7.5, ArH); 7.31-7.37 (3H, m, ArH); 3.88 (1H, ddd, J = 7.5, J = 13.5, NCH)); 3.71 (1H, ddd, J = 7.5, J = 13.5, NCH); 3.26-3.10 (2H, m, J = 7.5, COCH 2 ); 2.82 (2H, t, J = 7.5, COCH 2 ); 2.54 (2H, t, J = 7.5, SCH 2 ). 13 C NMR spectrum, δ, ppm: 179.21 (C (12) ); 172.62 (C (11) ); 166.86 (C (13) ); 143.59 (C (2) ); 133.98 (C (3) ); 129.31 (C (4) ); 128.68 (C (6) ); 128.45 (C (5) ); 127.12 (C (1) ); 47.63 (C (7) ); 33.78 (C (8) ); 30.54 (C (10) ); 27.49 (C (9) ). Found, %: C 50.83; H 5.62; N 9.11.…”

Unexpected transformation of ethyl 1-(4-chlorophenyl)-2-methyl-4-oxo-1,4,5,6-tetrahydropyridine-3-carboxylate and antibacterial activity of the products

“…They are perfect precursors for the synthesis of four-membered [1][2][3], five-membered [4], six-membered [5][6][7][8][9][10][11], and seven-membered [12,13] heterocycles possessing valuable practical properties. Oxohydropyridines, one class of the cyclization products of N-substituted b-amino acids, are very important intermediates in the synthesis of a large number of biologically active heterocyclic compounds [14,15].…”