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Synthesis and anti-bacterial activities of novel 5-isonicotinoyl-1,2,3,4-tetrahydropyrimidines and bis-(5-isonicotinoyl-1,2,3,4-tetrahydropyrimidines)

“…The protons at C-4 of the THP ring resonated just below 4.00 ppm except in cases where phenyl group is attached to N-3, while those bonded to C-2 were more de-shielded and resonated in the vicinity of 4.50 ppm. In the 13 C nmr spectra of the THPs, the most striking signal was due to carbonyl carbon (close to 190 ppm). Subsequently, the reaction of 3 with diamines and formaldehyde was examined.…”

“…The IR spectra were recorded on a Perkin-Elmer 983 spectrometer. 1 H NMR and 13 C NMR spectra were recorded on Bruker ACF-300 spectrometer. The chemical shifts (δ ppm) and the coupling constants (Hz) are reported in the standard fashion with reference to TMS as internal reference.…”

“…11 As a result, many research groups are turning their attention to the synthesis of bis-heterocycles. [12][13][14][15] Prompted by the promising biological properties of the tetrahydropyrimidines and hence bis-tetrahydropyrimidines bearing electron-withdrawing groups in position 5 of the ring, we decided to develop synthetic methodologies for 5-isonicotinoyl-1,2,3,4-tetrahydropyrimidines and bis-(5-isonicotinoyl-1,2,3,4-tetrahydropyrimidines) and the results of our studies are reported herein. Antibacterial properties of 5-isonicotinoyl-1,2,3,4-tetrahydropyrimidine derivatives have been studied and the results are presented in this paper.…”

Synthesis of 2,6-bis-polyfluoroalkyl-4H-pyran-4-ones

“…5 However, under these conditions dehydration proceeded to the end only for di-and trifluoromethyl substituted TK, whereas with the higher substituents γ-pyrones were obtained as by-products. …”

“…In the present paper the cyclization of bis-polyfluoroalkyl-1,3,5-triketones 1c-e,h-j (or their cyclic hydrates 1a,b,f,g) 5 to form 2,6-bis-polyfluoroalkyl-4H-pyran-4-ones by the action of various dehydrating agents has been investigated, and the selection of the optimal conditions for the dehydration has been made.…”