3D Network on Chip (NoC) has emerged as a new platform to meet the performance requirements and scaling challenges of System on Chip. More investigations require addressing challenges in multiport topologies, minimizing foot printing of nodes and interconnections of wires. This paper discusses multi-port NoC topologies and routing in 2D hexagonal and 3D mesh NoC. Deadlock free routing for 2D hexagonal mesh topology is compared to ZXY routing in 3D mesh with similar number of nodes. Routing algorithms shows promising results, thus making the architecture and algorithm more suitable for the future NoC design.