2023
DOI: 10.1002/adhm.202202609
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3D Biomimetic Models to Reconstitute Tumor Microenvironment In Vitro: Spheroids, Organoids, and Tumor‐on‐a‐Chip

Abstract: Decades of efforts in engineering in vitro cancer models have advanced drug discovery and the insight into cancer biology. However, the establishment of preclinical models that enable fully recapitulating the tumor microenvironment remains challenging owing to its intrinsic complexity. Recent progress in engineering techniques has allowed the development of a new generation of in vitro preclinical models that can recreate complex in vivo tumor microenvironments and accurately predict drug responses, including … Show more

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Cited by 33 publications
(17 citation statements)
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“…Tumor heterogeneity is credited to significant differences in tumor proliferation and invasion [ 74 ], and the model to address tumor heterogeneity is critical for assessing nanomedicine for tumor diagnosis and treatment. To pursue an animal model that mimics a complex and realistic physiological or pathological environment in patient [ 75 ], patient-derived xenograft (PDX) models have been developed, and they have a number of advantages. The PDX model is built by transplanting tumor tissues from patients into critically immunodeficient mice.…”
Section: Models For Evaluation Of the Degree Of Tumor Penetrationmentioning
confidence: 99%
“…Tumor heterogeneity is credited to significant differences in tumor proliferation and invasion [ 74 ], and the model to address tumor heterogeneity is critical for assessing nanomedicine for tumor diagnosis and treatment. To pursue an animal model that mimics a complex and realistic physiological or pathological environment in patient [ 75 ], patient-derived xenograft (PDX) models have been developed, and they have a number of advantages. The PDX model is built by transplanting tumor tissues from patients into critically immunodeficient mice.…”
Section: Models For Evaluation Of the Degree Of Tumor Penetrationmentioning
confidence: 99%
“…There are various advantages of the 3D organoids model (Table 4 ). One of the major advantages of 3D organoids is their ability to recreate complex tumor microenvironments in a controlled laboratory environment [ 103 ]. 3D organoids provide a more physiologically relevant model for assessing the effects of PI3K inhibitors.…”
Section: Predictive Medicine Approach To Breast Cancermentioning
confidence: 99%
“…Bioengineered tumor models, particularly tumoroid-based in vitro models, have shown promise in evaluating the efficacy of current anticancer drugs and the development of new therapies [33,34]. Tumor spheroids have the potential to create higher-order cellular tissue organization and better replicate the real tissue microenvironment [35].…”
Section: In Vitro Tumoroid Toxicity Assaymentioning
confidence: 99%