3D-bioprinted patient-specific organotypic bone model mimicking mineralization dysregulation inFKBP10-related osteogenesis imperfecta
Julia Griesbach,
Anke de Leeuw,
Tanja Minacci
et al.
Abstract:Osteogenesis imperfecta (OI) is a heterogeneous group of rare genetic diseases characterized by increased bone fragility and deformities. The pathomechanisms of OI are poorly understood, hindering the development of disease-specific therapy. Addressing the limited understanding of OI and the lack of targeted treatments remains a challenge, given its varied symptoms and large clinical spectrum. Animal models have greatly advanced the understanding of the disease; however, the heterogeneity and subtype-specific … Show more
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