3D bioprinted scaffolds for diabetic wound-healing applications

Abstract

The treatment strategy required for the effective healing of diabetic foot ulcer (DFU) is a complex process that is requiring several combined therapeutic approaches. As a result, there is a significant clinical and economic burden associated in treating DFU. Furthermore, these treatments are often unsuccessful, commonly resulting in lower-limb amputation. The use of drug-loaded scaffolds to treat DFU has previously been investigated using electrospinning and fused deposition modelling (FDM) 3D printing techniques; however, the rapidly evolving field of bioprinting is creating new opportunities for innovation within this research area. In this study, 3D-bioprinted scaffolds with different designs have been fabricated for the delivery of an antibiotic (levoflocixin) to DFU. The scaffolds were fully characterised by a variety of techniques (e.g. SEM, DSC/TGA, FTIR, and mechanical characterisation), demonstrating excellent mechanical properties and providing sustained drug release for 4 weeks. This proof of concept study demonstrates the innovative potential of bioprinting technologies in fabrication of antibiotic scaffolds for the treatment of DFU. Graphical abstract

Cefazolin Loaded Oxidized Regenerated Cellulose/Polycaprolactone Bilayered Composite for Use as Potential Antibacterial Dural Substitute

“…Cefazolin loaded PCL was weaker and less ductile after cefazolin loading since the tensile strength and strain at break decreased with increasing cefazolin concentration, while the tensile modulus was relatively unchanged ( Figure 3 b,d,f). This was consistent with the previous findings for other types of drug loaded PCL [ 35 , 36 , 37 , 38 ]. In contrast, tensile strength of cefazolin loaded ORC/PCL bilayered composite was unaffected, but the increase in tensile modulus and the decrease in strain at break with increasing cefazolin concentration were observed instead ( Figure 3 a,e).…”

Bibliometric analysis of systematic review and meta-analysis on diabetic foot ulcer

“…Meta-analysis synthesizes aspects of controversial diagnostic strategies, treatments, and epidemiological evidence that are commonly used in clinical practice to support decision-making with data of a higher level of evidence [ 25 ]. Given the difficulties in the management of diabetic foot ulcers, clinical studies of diverse therapeutic measures have flourished [ 9 , [26] , [27] , [28] ]. Gaining insights into the publication trends and characteristics of these studies holds great importance for clinicians and the general public.…”

Bioinspired 3D-printed scaffold embedding DDAB-nano ZnO/nanofibrous microspheres for regenerative diabetic wound healing

“…Scaffolds for regenerative healing of cutaneous wounds should secure adequate mechanical strength for maintaining structural stability and porosity essential for tissue regeneration [68]. Simultaneously, they should be sufficiently elastic to provide mechanical support for regenerated tissue and adapt to the natural skin stretching during the normal body movement [69]. The developed scaffolds were characterized for Young's modulus and ultimate strength as parameters indicative of deformation ability and mechanical strength, respectively.…”