3D Bioprinting for Pancreas Engineering/Manufacturing

Abstract

Diabetes is the most common chronic disease in the world, and it brings a heavy burden to people’s health. Against this background, diabetic research, including islet functionalization has become a hot topic in medical institutions all over the world. Especially with the rapid development of microencapsulation and three-dimensional (3D) bioprinting technologies, organ engineering and manufacturing have become the main trends for disease modeling and drug screening. Especially the advanced 3D models of pancreatic islets have shown better physiological functions than monolayer cultures, suggesting their potential in elucidating the behaviors of cells under different growth environments. This review mainly summarizes the latest progress of islet capsules and 3D printed pancreatic organs and introduces the activities of islet cells in the constructs with different encapsulation technologies and polymeric materials, as well as the vascularization and blood glucose control capabilities of these constructs after implantation. The challenges and perspectives of the pancreatic organ engineering/manufacturing technologies have also been demonstrated.

Impresión o bioimpresión 3D en el área de la salud. Revisión de la literatura

“…La bioimpresión 3D es un concepto pionero que aprovecha las impresoras y técnicas 3D para generar estructuras tridimensionales compuestas de materiales biológicos, con la capacidad de combinar células y biomateriales capa por capa. La bioimpresión 3D es una tecnología de vanguardia que permite la producción de estructuras tridimensionales utilizando células vivas y biomateriales (6,24,25). Esta metodología innovadora emplea tintas biológicas y técnicas de impresión para fabricar réplicas de órganos funcionales para pacientes que requieren un trasplante de órganos (26).…”

Recent advances in the development of bioartificial pancreas using 3D bioprinting for the treatment of type 1 diabetes: a review

“…Additionally, MSCs also promote angiogenesis by remodeling the ECM, secreting pro-angiogenic factors like VEGF, angiopoietin 1 (Ang 1), Ang 2, and stabilizing vasculature [201]. However, controlling the vascularization process and the proper organization of microvascular networks within bioprinted constructs remain a challenging task to date [202].…”

Chondrocyte harvest viability of auricular and nasal septal cartilage in a sheep model

“…Contemporary bioprinting techniques typically involve the creation of a biodegradable scaffold for "bioinks" consisting of living cells, supporting structures such as hydrogel matrices and additional biological motifs such as growth factors (Chung et al, 2020a). In recent years, this had been popularised through research into bioprinted organs such as the pancreas or liver, where pancreatic islets or hepatocytes are used as living cells in the bioinks (Kryou et al, 2019;Xu et al, 2022).…”