3D Bioprinting for Tumor Metastasis Research

Lin, Manqing; Tang, Mengyi; Duan, Wenzhe; Xia, Shengkai; Liu, Wenwen; Wang, Qi

doi:10.1021/acsbiomaterials.3c00239

Cited by 6 publications

(3 citation statements)

References 231 publications

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“…3D bioprinting is an emerging technology in which bioactive materials are used as bioinks to construct 3D structures according to a designed model, and it holds great promise for modelling human diseases 88 . 3D bioprinting enables the better simulation of the microenvironment and the incorporation of perfusable vascular networks into large tissue structures, thus mimicking bidirectional interactions between tumour cells and ECs 89 . The introduction of decellularised ECM (dECM), a bio‐ink printing material, plays a key role in studying the interaction between tumour cells and ECs in the brain due to its better cytocompatibility 90 .…”

Section: New Models For the Examination Of Tumour Cell–ec Interactionmentioning

confidence: 99%

Targeting of endothelial cells in brain tumours

Duan,

Xia,

Tang

et al. 2023

Clinical & Translational Med

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BackgroundAggressive brain tumours, whether primary gliomas or secondary metastases, are characterised by hypervascularisation and are fatal. Recent research has emphasised the crucial involvement of endothelial cells (ECs) in all brain tumour genesis and development events, with various patterns and underlying mechanisms identified.Main bodyHere, we highlight recent advances in knowledge about the contributions of ECs to brain tumour development, providing a comprehensive summary including descriptions of interactions between ECs and tumour cells, the heterogeneity of ECs and new models for research on ECs in brain malignancies. We also discuss prospects for EC targeting in novel therapeutic approaches.ConclusionInterventions targeting ECs, as an adjunct to other therapies (e.g. immunotherapies, molecular‐targeted therapies), have shown promising clinical efficacy due to the high degree of vascularisation in brain tumours. Developing precise strategies to target tumour‐associated vessels based on the heterogeneity of ECs is expected to improve anti‐vascular efficacy.

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Section: New Models For the Examination Of Tumour Cell–ec Interactionmentioning

confidence: 99%

Targeting of endothelial cells in brain tumours

Duan,

Xia,

Tang

et al. 2023

Clinical & Translational Med

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“…The complexities of tumor microenvironments have proven challenging to understand using conventional techniques [16,17]. However, the field has completely changed with the development of 3D bioprinting technology, which provides an entirely novel technique for in vitro replication of the intricate architecture of tumors [36][37][38][39]. This development may lead to the discovery of novel treatment approaches to stop tumor angiogenesis and the spread of metastatic disease by providing insights into the fundamental principles of cancer vasculogenesis [36,37,40].…”

Section: Introductionmentioning

confidence: 99%

Advancement in Cancer Vasculogenesis Modeling through 3D Bioprinting Technology

Shukla,

Yoon,

et al. 2024

Biomimetics

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Cancer vasculogenesis is a pivotal focus of cancer research and treatment given its critical role in tumor development, metastasis, and the formation of vasculogenic microenvironments. Traditional approaches to investigating cancer vasculogenesis face significant challenges in accurately modeling intricate microenvironments. Recent advancements in three-dimensional (3D) bioprinting technology present promising solutions to these challenges. This review provides an overview of cancer vasculogenesis and underscores the importance of precise modeling. It juxtaposes traditional techniques with 3D bioprinting technologies, elucidating the advantages of the latter in developing cancer vasculogenesis models. Furthermore, it explores applications in pathological investigations, preclinical medication screening for personalized treatment and cancer diagnostics, and envisages future prospects for 3D bioprinted cancer vasculogenesis models. Despite notable advancements, current 3D bioprinting techniques for cancer vasculogenesis modeling have several limitations. Nonetheless, by overcoming these challenges and with technological advances, 3D bioprinting exhibits immense potential for revolutionizing the understanding of cancer vasculogenesis and augmenting treatment modalities.

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“…These models are instrumental in advancing personalized medicine, offering a promising approach for diverse research applications within the fields of oncology and pharmaceuticals. [14][15][16] This review aims to focus on the simulation of TME models using 3D bioprinting technology. It summarizes the research progress in the application of 3D bioprinting to simulate TME in various cancers, encompassing the technology itself, the simulated components of the models, and their interactions.…”

Section: Introductionmentioning

confidence: 99%

3D Bioprinting: An Important Tool for Tumor Microenvironment Research

Li,

Liu,

et al. 2023

IJN

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The tumor microenvironment plays a crucial role in cancer development and treatment. Traditional 2D cell cultures fail to fully replicate the complete tumor microenvironment, while mouse tumor models suffer from time-consuming procedures and complex operations. However, in recent years, 3D bioprinting technology has emerged as a vital tool in studying the tumor microenvironment. 3D bioprinting is a revolutionary biomanufacturing technique that involves layer-by-layer stacking of biological materials, such as cells and biomaterial scaffolds, to create highly precise 3D biostructures. This technology enables the construction of intricate tissue and organ models in the laboratory, which are utilized for biomedical research, drug development, and personalized medicine. The application of 3D bioprinting has brought unprecedented opportunities to fields such as cancer research, tissue engineering, and organ transplantation. It has opened new possibilities for addressing real-world biological challenges and improving medical treatment outcomes. This review summarizes the applications of 3D bioprinting technology in the context of the tumor microenvironment, aiming to explore its potential impact on cancer research and treatment. The use of this cutting-edge technology promises significant advancements in understanding cancer biology and enhancing medical interventions.

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3D Bioprinting for Tumor Metastasis Research

Cited by 6 publications

References 231 publications

Targeting of endothelial cells in brain tumours

Targeting of endothelial cells in brain tumours

Advancement in Cancer Vasculogenesis Modeling through 3D Bioprinting Technology

3D Bioprinting: An Important Tool for Tumor Microenvironment Research

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