3D bioprinting of articular cartilage: Recent advances and perspectives

Dufaud, Marjorie; Solé, Lilian; Maumus, Marie; Simon, Matthieu; Perrier‐Groult, Emeline; Subra, Gilles; Jørgensen, Christian; Noël, Danièle

doi:10.1016/j.bprint.2022.e00253

Cited by 8 publications

(2 citation statements)

References 124 publications

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“…Several studies have utilized different synthetic biomaterials such as polyethylene glycol (PEG), dimethacrylate (PEGDMA) [29], alginate-nanocellulose, HA and gelatin methacrylate (GelMA) [30]. The differentiation of MSCs was dependent upon biomaterials such as agarose, alginate, GelMA and PEGDMA [31], and was experimentally proved in a study which involved encapsulated MSCs laid on RGD-functionalized PEGDMA hydrogel [32]. Very recently, a silk-based natural polymer, silk fibroin methacrylate (SilMA), exhibited an appreciable potency in improving cell adhesion and fabrication of scaffolds in bones and also in cartilage.…”

Section: Sequel Of Bones and Cartilaginous Tissue Modelsmentioning

confidence: 99%

Out of Box Thinking to Tangible Science: A Benchmark History of 3D Bio-Printing in Regenerative Medicine and Tissues Engineering

Pushparaj

Balasubramanian

Pappuswamy

et al. 2023

Life

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Advancements and developments in the 3D bioprinting have been promising and have met the needs of organ transplantation. Current improvements in tissue engineering constructs have enhanced their applications in regenerative medicines and other medical fields. The synergistic effects of 3D bioprinting have brought technologies such as tissue engineering, microfluidics, integrated tissue organ printing, in vivo bioprinted tissue implants, artificial intelligence and machine learning approaches together. These have greatly impacted interventions in medical fields, such as medical implants, multi-organ-on-chip models, prosthetics, drug testing tissue constructs and much more. This technological leap has offered promising personalized solutions for patients with chronic diseases, and neurodegenerative disorders, and who have been in severe accidents. This review discussed the various standing printing methods, such as inkjet, extrusion, laser-assisted, digital light processing, and stereolithographic 3D bioprinter models, adopted for tissue constructs. Additionally, the properties of natural, synthetic, cell-laden, dECM-based, short peptides, nanocomposite and bioactive bioinks are briefly discussed. Sequels of several tissue-laden constructs such as skin, bone and cartilage, liver, kidney, smooth muscles, cardiac and neural tissues are briefly analyzed. Challenges, future perspectives and the impact of microfluidics in resolving the limitations in the field, along with 3D bioprinting, are discussed. Certainly, a technology gap still exists in the scaling up, industrialization and commercialization of this technology for the benefit of stakeholders.

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Section: Sequel Of Bones and Cartilaginous Tissue Modelsmentioning

confidence: 99%

Out of Box Thinking to Tangible Science: A Benchmark History of 3D Bio-Printing in Regenerative Medicine and Tissues Engineering

Pushparaj

Balasubramanian

Pappuswamy

et al. 2023

Life

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show abstract

“…Originally utilized for digital printing of (colored) inks for print media, DOD has emerged as a well-established tool in multiple fields. It is utilized in the fields of additive manufacturing (3D printing) [ 1 ], bioprinting [ 2 , 3 ], manufacturing of flexible (bio)sensors [ 4 , 5 ], high-throughput screening and micro arraying for biotechnological/pharmaceutical research [ 3 ] or even for display manufacturing [ 6 ], as some representative examples.…”

Section: Introductionmentioning

confidence: 99%

Influence of the Volatility of Solvent on the Reproducibility of Droplet Formation in Pharmaceutical Inkjet Printing

Mau

Seitz

2023

Pharmaceutics

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Drop-on-demand (DOD) inkjet printing enables exact dispensing and positioning of single droplets in the picoliter range. In this study, we investigate the long-term reproducibility of droplet formation of piezoelectric inkjet printed drug solutions using solvents with different volatilities. We found inkjet printability of EtOH/ASA drug solutions is limited, as there is a rapid forming of drug deposits on the nozzle of the printhead because of fast solvent evaporation. Droplet formation of c = 100 g/L EtOH/ASA solution was affected after only a few seconds by little drug deposits, whereas for c = 10 g/L EtOH/ASA solution, a negative affection was observed only after t = 15 min, while prominent drug deposits form at the printhead tip. Due to the creeping effect, the crystallizing structures of ASA spread around the nozzle but do not clog it necessarily. When there is a negative affection, the droplet trajectory is affected the most, while the droplet volume and droplet velocity are influenced less. In contrast, no formation of drug deposits could be observed for highly concentrated, low volatile DMSO-based drug solution of c = 100 g/L even after a dispensing time of t = 30 min. Therefore, low volatile solvents are preferable to highly volatile solvents to ensure a reproducible droplet formation in long-term inkjet printing of highly concentrated drug solutions. Highly volatile solvents require relatively low drug concentrations and frequent printhead cleaning. The findings of this study are especially relevant when high droplet positioning precision is desired, e.g., drug loading of microreservoirs or drug-coating of microneedle devices.

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The Effect of the Mechanical Properties of the 3D Printed Gelatin/Hyaluronic Acid Scaffolds on hMSCs Differentiation Towards Chondrogenesis

Choi

Park

Choi

et al. 2023

Tissue Eng Regen Med

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3D bioprinting of articular cartilage: Recent advances and perspectives

Cited by 8 publications

References 124 publications

Out of Box Thinking to Tangible Science: A Benchmark History of 3D Bio-Printing in Regenerative Medicine and Tissues Engineering

Out of Box Thinking to Tangible Science: A Benchmark History of 3D Bio-Printing in Regenerative Medicine and Tissues Engineering

Influence of the Volatility of Solvent on the Reproducibility of Droplet Formation in Pharmaceutical Inkjet Printing

The Effect of the Mechanical Properties of the 3D Printed Gelatin/Hyaluronic Acid Scaffolds on hMSCs Differentiation Towards Chondrogenesis

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