3D Bioprinting of Hydrogels for Cartilage Tissue Engineering

Huang, Jianghong; Xiong, Jianyi; Wang, Daping; Zhang, Jun; Yang, Lei; Sun, Shuqing; Liang, Yujie

doi:10.3390/gels7030144

Cited by 66 publications

(45 citation statements)

References 75 publications

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“…Most recent studies have used 3D bioprinting technology to prepare NC hydrogel scaffolds that have been used for cartilage repairs [ 108 ]. For example, Park et al used glycidyl methacrylate (GMA)-modified silk fibroin (Sil-MA) hydrogel as a biological ink and showed show that Sil-MA hydrogels were biocompatible, and their complex structures could be prepared by 3D bioprinting [ 109 , 110 ].…”

Section: Fabrication Of Nanocomposite Hydrogelsmentioning

confidence: 99%

Advanced Nanocomposite Hydrogels for Cartilage Tissue Engineering

Huang

Liu

Su³

et al. 2022

Gels

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Tissue engineering is becoming an effective strategy for repairing cartilage damage. Synthesized nanocomposite hydrogels mimic the structure of natural cartilage extracellular matrices (ECMs), are biocompatible, and exhibit nano–bio effects in response to external stimuli. These inherent characteristics make nanocomposite hydrogels promising scaffold materials for cartilage tissue engineering. This review summarizes the advances made in the field of nanocomposite hydrogels for artificial cartilage. We discuss, in detail, their preparation methods and scope of application. The challenges involved for the application of hydrogel nanocomposites for cartilage repair are also highlighted.

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Section: Fabrication Of Nanocomposite Hydrogelsmentioning

confidence: 99%

Advanced Nanocomposite Hydrogels for Cartilage Tissue Engineering

Huang

Liu

Su³

et al. 2022

Gels

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“…Inkjet bioprinting is the deposition of low viscosity bioink onto a substrate in extremely small volumes (i.e., 1-100 picolitres) [78]. The principle of bioprinting is that a liquid biomaterial is printed layer-by-layer until the entire object is constructed.…”

Section: Inkjet-based 3d Bioprintingmentioning

confidence: 99%

Applications of 3D Bioprinting Technology in Induced Pluripotent Stem Cells-Based Tissue Engineering

2022

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Induced pluripotent stem cells (iPSCs) are essentially produced by the genetic reprogramming of adult cells. Moreover, iPSC technology prevents the genetic manipulation of embryos. Hence, with the ensured element of safety, they rarely cause ethical concerns when utilized in tissue engineering. Several cumulative outcomes have demonstrated the functional superiority and potency of iPSCs in advanced regenerative medicine. Recently, an emerging trend in 3D bioprinting technology has been a more comprehensive approach to iPSC-based tissue engineering. The principal aim of this review is to provide an understanding of the applications of 3D bioprinting in iPSC-based tissue engineering. This review discusses the generation of iPSCs based on their distinct purpose, divided into two categories: (1) undifferentiated iPSCs applied with 3D bioprinting; (2) differentiated iPSCs applied with 3D bioprinting. Their significant potential is analyzed. Lastly, various applications for engineering tissues and organs have been introduced and discussed in detail.

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“…The pore structures provide spaces for accommodation of the proliferated cells and secreted extracellular matrices (ECM). In contrast, hydrogels are water-swollen networks that are covalently or physically crosslinked [ 21 , 22 ]. Cells embedded in hydrogels are surrounded by water-swollen networks that resemble the extracellular microenvironments surrounding cells in vivo [ 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Stepwise Proliferation and Chondrogenic Differentiation of Mesenchymal Stem Cells in Collagen Sponges under Different Microenvironments

Zheng

Xie

Yoshitomi

et al. 2022

IJMS

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Biomimetic microenvironments are important for controlling stem cell functions. In this study, different microenvironmental conditions were investigated for the stepwise control of proliferation and chondrogenic differentiation of human bone-marrow-derived mesenchymal stem cells (hMSCs). The hMSCs were first cultured in collagen porous sponges and then embedded with or without collagen hydrogels for continual culture under different culture conditions. The different influences of collagen sponges, collagen hydrogels, and induction factors were investigated. The collagen sponges were beneficial for cell proliferation. The collagen sponges also promoted chondrogenic differentiation during culture in chondrogenic medium, which was superior to the effect of collagen sponges embedded with hydrogels without loading of induction factors. However, collagen sponges embedded with collagen hydrogels and loaded with induction factors had the same level of promotive effect on chondrogenic differentiation as collagen sponges during in vitro culture in chondrogenic medium and showed the highest promotive effect during in vivo subcutaneous implantation. The combination of collagen sponges with collagen hydrogels and induction factors could provide a platform for cell proliferation at an early stage and subsequent chondrogenic differentiation at a late stage. The results provide useful information for the chondrogenic differentiation of stem cells and cartilage tissue engineering.

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3D Bioprinting of Hydrogels for Cartilage Tissue Engineering

Cited by 66 publications

References 75 publications

Advanced Nanocomposite Hydrogels for Cartilage Tissue Engineering

Advanced Nanocomposite Hydrogels for Cartilage Tissue Engineering

Applications of 3D Bioprinting Technology in Induced Pluripotent Stem Cells-Based Tissue Engineering

Stepwise Proliferation and Chondrogenic Differentiation of Mesenchymal Stem Cells in Collagen Sponges under Different Microenvironments

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