2024
DOI: 10.1002/adfm.202315488
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3D Bioprinting of Multicellular Stem Cell‐Derived Constructs to Model Pancreatic Cell Differentiation

Shlomit Edri,
Abigail Newman Frisch,
Dina Safina
et al.

Abstract: In vitro models of the pancreas can aid in developing therapies for pancreatic diseases. Nonetheless, most pancreatic tissue engineering is limited to insulin‐secreting β‐cells or pancreatic adenocarcinoma models. Combining all essential tissue components, including exocrine, endocrine, and blood vasculature, is crucial to recapitulate native tissue organization. In this study, extrusion‐based 3D bioprinting to create pancreatic tissue constructs containing both endocrine and exocrine compartments is exploited… Show more

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Cited by 2 publications
(2 citation statements)
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“…The study of hypoxia-induced angiogenesis and the development of cutting-edge therapeutic strategies that target tumor angiogenesis have been made possible by 3D bioprinted models. Considering these developments, it is still challenging for researchers to find appropriate biomaterials that replicate the microenvironment of pancreatic tumors, which restricts the applicability of findings from studies into clinical application [78,79].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…The study of hypoxia-induced angiogenesis and the development of cutting-edge therapeutic strategies that target tumor angiogenesis have been made possible by 3D bioprinted models. Considering these developments, it is still challenging for researchers to find appropriate biomaterials that replicate the microenvironment of pancreatic tumors, which restricts the applicability of findings from studies into clinical application [78,79].…”
Section: Introductionmentioning
confidence: 99%
“…The use of patient-derived cells also presents limitations, such as the difficulty in obtaining a sufficient number of cells and the potential for genetic drift during culture. In conclusion, while vasculogenesis modeling can enhance our understanding of cancer biology and treatment, it is crucial to overcome these challenges to broaden the application of the model to various cancer types and tissues [78,80].…”
Section: Introductionmentioning
confidence: 99%