3D Bioprinting Technology and Hydrogels Used in the Process

Lima, Tainara de P. L.; Canelas, Caio Augusto de Almeida; Concha, Víktor Oswaldo Cárdenas; Costa, F.M.; Passos, Marcele Fonseca

doi:10.3390/jfb13040214

Cited by 11 publications

(5 citation statements)

References 186 publications

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“…However, the delicate nature of the hydrogel results in fragile and mechanically unstable constructs. [143] Furthermore, cells in a bio- License. [142] Copyright 2022, The Authors, published by SAGE Publications.…”

Section: Construction Of Biomimetic Organ/tissue Constructmentioning

confidence: 99%

“…However, the delicate nature of the hydrogel results in fragile and mechanically unstable constructs. [ 143 ] Furthermore, cells in a bioprinted construct are usually embedded in crosslinked hydrogel, therefore a diffusion limit, which is ≈100–200 µm for oxygen in hydrogels resulting in insufficient cellular access to nutrients and oxygen, is one of the challenges in the bioprinted construct. [ 19 ]…”

Section: Application Of Nfm Fabrication Techniques For Construction O...mentioning

confidence: 99%

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Recent Progress in Fabrication of Electrospun Nanofiber Membranes for Developing Physiological In Vitro Organ/Tissue Models

Kim,

Youn,

Lee

et al. 2023

Macromolecular Bioscience

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Nanofiber membranes (NFMs), which have an extracellular matrix (ECM)‐mimicking structure and unique physical properties, have garnered great attention as biomimetic materials for developing physiologically relevant in vitro organ/tissue models. Recent progress in NFM fabrication techniques immensely contributed to the development of NFM‐based cell culture platforms for constructing physiological organ/tissue models. However, despite the significance of the NFM fabrication technique, an in‐depth discussion of the fabrication technique and its future aspect was insufficient. This review provides an overview of the current state‐of‐the‐art of NFM fabrication techniques from electrospinning techniques to post‐processing techniques for the fabrication of various types of NFM‐based cell culture platforms. Moreover, the advantages of the NFM‐based culture platforms in the construction of organ/tissue models are discussed especially for tissue barrier models, spheroids/organoids, and biomimetic organ/tissue constructs. Finally, the review concludes with perspectives on challenges and future directions for fabrication and utilization of NFMs.This article is protected by copyright. All rights reserved

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Section: Construction Of Biomimetic Organ/tissue Constructmentioning

confidence: 99%

Section: Application Of Nfm Fabrication Techniques For Construction O...mentioning

confidence: 99%

Recent Progress in Fabrication of Electrospun Nanofiber Membranes for Developing Physiological In Vitro Organ/Tissue Models

Kim,

Youn,

Lee

et al. 2023

Macromolecular Bioscience

View full text Add to dashboard Cite

show abstract

“…However, pure alginate lacks functional groups that stimulate cell adhesion and proliferation. It also has low mechanical properties [82,96]. Alternative studies have shown that combining alginate with other biomaterials-for example, collagen and gelatin-revealed promising results, mainly improving cell adhesion and proliferation.…”

Section: Biomaterialsmentioning

confidence: 99%

Trends and Technological Challenges of 3D Bioprinting in Cultured Meat: Technological Prospection

Barbosa,

Correia,

Vieira

et al. 2023

Applied Sciences

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Cultured meat presents a possible alternative to conventional meat products and may be used to address growing food demands attributable to global population growth. Thus, a comprehensive technological prospection of the scientific literature related to cultured meat produced by 3D bioprinting is of great interest to researchers. The purpose of this article is to review and analyze published studies related to the biofabrication of cultured meat using 3D bioprinting techniques. The growing number of related publications in recent years highlights that cultured meat has gained traction in the scientific community. Furthermore, private companies and startups have contributed to advancements in the biofabrication of cultured meat for consumption, illustrating that cultured meat as a conventional meat substitute is already becoming reality. However, like any scientific advance, 3D bioprinting of cultured meat faces challenges involving regulation, acceptance, the selection of ideal biomaterials and cell lines, the replacement of fetal bovine serum (FBS), and attaining a texture and nutritional value similar to those of conventional meat.

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“…The most relevant and widely used 3D bioprinting approaches for the engineering of 3D constructs include inkjet-based (Angelopoulos et al, 2020;Prabhakaran et al, 2022), laser-assisted (Heinrich et al, 2019), and extrusion-based bioprinting (Jeong et al, 2020). The specifics of these 3D bioprinting technologies are beyond the scope of this review and can be found in details elsewhere (Chameettachal et al, 2019;Cidonio et al, 2019;Scognamiglio et al, 2020;Lima et al, 2022;Karvinen and Kellomäki, 2023;Sabzevari et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

Unravelling hierarchical patterning of biomaterial inks with 3D microfluidic-assisted spinning: a paradigm shift in bioprinting technologies

Mohammadi,

Cidonio

2023

Front. Biomater. Sci.

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For decades, 3D bioprinting has offered a revolutionising approach to combine living cells and biomaterials to engineer complex, yet functional constructs. However, traditional 3D bioprinting platforms fall short of the ability to pattern complex gradients of biomaterials, cells, and ultimately bio-physical properties to drive tissue formation and regeneration. Recently, 3D microfluidic-assisted bioprinting (3DMB) has risen as a new hybrid approach for the fabrication of physiologically relevant tissues, adopting a microfluidic chip as functional printhead to achieve hierarchical patterning of bioinks and precise control over the microscale architecture of printed constructs, enabling the creation of multi-layered tissues. This review explores recent advancements in graded biomaterial patterning using microfluidic-assisted spinning and novel 3D bioprinting technologies. The physiological hierarchical arrangement of human tissues and the crucial role of biomaterials in achieving ordered assembly is hereby discussed. Lastly, the integration of microfluidic-assisted techniques with new bioprinting platforms is highlighted, examining the latest advancements in tissue regeneration and disease modelling.

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3D Bioprinting Technology and Hydrogels Used in the Process

Cited by 11 publications

References 186 publications

Recent Progress in Fabrication of Electrospun Nanofiber Membranes for Developing Physiological In Vitro Organ/Tissue Models

Recent Progress in Fabrication of Electrospun Nanofiber Membranes for Developing Physiological In Vitro Organ/Tissue Models

Trends and Technological Challenges of 3D Bioprinting in Cultured Meat: Technological Prospection

Unravelling hierarchical patterning of biomaterial inks with 3D microfluidic-assisted spinning: a paradigm shift in bioprinting technologies

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