In order to meet the real-time communication between teachers and students and improve students' interest and efficiency in learning, this paper designs a mobile learning communication system based on information security and Android system with cloud computing. By using the method of combining database records and web logs to mine the user's browsing records and behaviors, these implicit user behaviors are transformed into explicit user evaluations of the project. Then, the cosine similarity calculation method is used to calculate users and the similarity between the users. The users are clustered by the K-means clustering method, so that the users are automatically divided into several user clusters according to their behaviors. Finally, the user's nearest neighbor score is used to predict the pair. Based on the above method, a mobile learning communication system based on Android is realized, and the system basically meets the functional needs of users. The development of this system not only promotes the mutual communication between students but also facilitates the students' learning, which has a certain promoting effect on the improvement of their academic performance.