3D construct of hydroxyapatite/zinc oxide/palladium nanocomposite scaffold for bone tissue engineering

Heidari, Fatemeh; Tabatabaei, Fahimeh; Razavi, Mehdi; Bazargan‐Lari, Reza; Tavangar, Mina; Romanos, Georgios E.; Vashaee, Daryoosh; Tayebi, Lobat

doi:10.1007/s10856-020-06409-2

Cited by 20 publications

(7 citation statements)

References 58 publications

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“…[28][29][30] Zn 2+ is a kind of metal ion with biological activity, and it has been widely studied as a bone repair material because of its ability to improve the mechanical properties, increase new bone formation and inhibit bone resorption. 31,32 Adding ZnO to the material was a good way to dope Zn 2+ . 33,34 Akhmad Herman Yuwono et al 35 improve the antibacterial ability of hydroxyapatite/chitosan scaffold by adding different concentrations of ZnO.…”

Section: Introductionmentioning

confidence: 99%

Preparation and biological properties of ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin biomimetic composite scaffolds for bone tissue engineering

Liu

Feng

et al. 2022

J Biomater Appl

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To imitate the composition of natural bone and further improve the biological property of the materials, ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin (ZnO/HAP/CS-PEO@GEL) composite scaffolds were developed. The core-shell structured chitosan-polyethylene oxide@gelatin (CS-PEO@GEL) nanofibers which could form the intramolecular hydrogen bond and achieve an Arg-Gly-Asp (RGD) polymer were first prepared by coaxial electrospinning to mimic the extracellular matrix. To further enhance biological activity, hydroxyapatite (HAP) was grown on the surface of the CS-PEO@GEL nanofibers using chemical deposition and ZnO particles were then evenly distributed on the surface of the above composite materials using RF magnetron sputtering. The SEM results showed that chemical deposition and magnetron sputtering did not destroy the three-dimensional architecture of materials, which was beneficial to cell growth. The cell compatibility and proliferation of MG-63 cells on ZnO/HAP/CS-PEO@GEL composite scaffolds were superior to those on CS-PEO@GEL and HAP/CS-PEO@GEL composite scaffolds. An appropriate amount of ZnO sputtering could promote the adhesion of cells on the composite nanofibers. The structure of bone tissue could be better simulated both in composition and in the microenvironment, which provided a suitable environment for cell growth and promoted the proliferation of MG-63 cells. The biomimetic ZnO/HAP/CS-PEO@GEL composite scaffolds were promising materials for bone tissue engineering.

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Section: Introductionmentioning

confidence: 99%

Preparation and biological properties of ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin biomimetic composite scaffolds for bone tissue engineering

Liu

Feng

et al. 2022

J Biomater Appl

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“…The behavior of crack propagation and its rate in Ecoflex elastomers is distinct from that of other solid materials such as fiber-reinforced polymers [ 23 , 24 , 25 , 26 , 27 , 28 ] and other materials [ 29 , 30 ]. In most cases mentioned earlier, crack initiation begins from the designated notch position and travels parallel to it.…”

Section: Methodsmentioning

confidence: 99%

A Multiaxial Fracture of Ecoflex Skin with Different Shore Hardness for Morphing Wing Application

Ahmad

Ajaj

2023

Polymers

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The use of elastomer-based skins in morphing wings has become increasingly popular due to their remarkable stretchability and mechanical properties. However, the possibility of the skin fracturing during multiaxial stretching remains a significant design challenge. The propagation of cracks originating from flaws or notches in the skin can lead to the specimen breaking into two parts. This paper presents an experimental study aimed at comprehensively evaluating crack propagation direction, stretchability, and fracture toughness of silicone-based elastomeric skin (Ecoflex) for morphing wing applications, using varying Shore hardness values (10, 30, and 50). The findings show that the lower Shore hardness value of 10 exhibits a unique Sideways crack propagation characteristic, which is ideal for morphing skins due to its high stretchability, low actuation load, and high fracture toughness. The study also reveals that the Ecoflex 10 is suitable for use in span morphing, with a fracture toughness of approximately 1.1 kJ/m2 for all thicknesses at a slower strain rate of 0.4 mm/min. Overall, this work highlights the superior properties of Ecoflex 10 and its potential use as a morphing skin material, offering a groundbreaking solution to the challenges faced in this field.

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“…Similarly, Heidari et al (2020) reported palladium supplemented hybrid ZnOhydroxyapatite nanocomposite-based scaffolds where chitosan was used as a binder [69]. The HA/ZnO/Pd nanoparticles were irregular in shape with an average particle size of 70 nm.…”

Section: Platinum and Palladiummentioning

confidence: 98%

Metallic Nanoscaffolds as Osteogenic Promoters: Advances, Challenges and Scope

Ghosh

Webster

2021

Metals

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Bone injuries and fractures are often associated with post-surgical failures, extended healing times, infection, a lack of return to a normal active lifestyle, and corrosion associated allergies. In this regard, this review presents a comprehensive report on advances in nanotechnology driven solutions for bone tissue engineering. The fabrication of metals such as copper, gold, platinum, palladium, silver, strontium, titanium, zinc oxide, and magnetic nanoparticles with tunable physico-chemical and opto-electronic properties for osteogenic scaffolds is discussed here in detail. Furthermore, the rational selection of a polymeric base such as chitosan, collagen, poly (L-lactide), hydroxyl-propyl-methyl cellulose, poly-lactic-co-glycolic acid, polyglucose-sorbitol-carboxymethy ether, polycaprolactone, natural rubber latex, and silk fibroin for scaffold preparation is also discussed. These advanced materials and fabrication strategies not only provide for appropriate mechanical strength but also render integrity, making them appealing for orthopedic applications. Further, such scaffolds can be functionalized with ligands or biomolecules such as hydroxyapatite, polypyrrole (PPy), magnesium, zinc dopants, and growth factors to stimulate osteogenic differentiation, mineralization, and neovascularization to aid in rapid healing. Future directions to co-incorporate bioceramics, biogenic nanoparticles, and fourth generation biomaterials to enhance biocompatibility, mechanical properties, and rapid recovery are also included in this review. Hence, the further development of such biomimetic metal-based nano-scaffolds at a lower cost with reduced risks and greater efficacy at regrowing bone can revolutionize the future of orthopedics.

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3D construct of hydroxyapatite/zinc oxide/palladium nanocomposite scaffold for bone tissue engineering

Cited by 20 publications

References 58 publications

Preparation and biological properties of ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin biomimetic composite scaffolds for bone tissue engineering

Preparation and biological properties of ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin biomimetic composite scaffolds for bone tissue engineering

A Multiaxial Fracture of Ecoflex Skin with Different Shore Hardness for Morphing Wing Application

Metallic Nanoscaffolds as Osteogenic Promoters: Advances, Challenges and Scope

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