3D-cubic interconnected porous Mg-based scaffolds for bone repair

Dong, Qiangsheng; Li, Yang; Jiang, Hui; Zhou, Xingxing; Liu, Huan; Lu, Mengmeng; Chu, Chenglin; Xue, Feng; Bai, Jing

doi:10.1016/j.jma.2020.05.022

Cited by 46 publications

(34 citation statements)

References 48 publications

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“…Yet, the fabrication of magnesium scaffolds with controlled degree of porosity remains a challenge due to the requirement of connection between the pores and minimum diameter without compromising the overall structural integrity. Some of the techniques that have been used to produce magnesium scaffolds include additive manufacturing [8] and space holder techniques such as negative salt pattern molding [9][10][11][12] or entangled titanium wires [13]. These techniques prevent the use of thermo-mechanical processing to improve the properties of the material.…”

Section: Introductionmentioning

confidence: 99%

Mechanical Behavior and In Vitro Corrosion of Cubic Scaffolds of Pure Magnesium Processed by Severe Plastic Deformation

Silva

Câmara

Hohenwarter

et al. 2021

Metals

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Reports in the literature show that severe plastic deformation can improve mechanical strength, ductility, and corrosion resistance of pure magnesium, which suggests good performance for biodegradable applications. However, the reported results were based on testing of small samples on limited directions. The present study reports compression testing of larger samples, at different directions, in pure magnesium processed by hot rolling, equal channel angular pressing (ECAP), and high pressure torsion (HPT). The results show that severe plastic deformation through ECAP and HPT reduces anisotropy and increases strength and strain rate sensitivity. Also, scaffolds were fabricated from the material with different processing histories and immersed in Hank’s solution for up to 14 days. The as-cast material displays higher corrosion rate and localized corrosion and it is reported that severe plastic deformation induces uniform corrosion and reduces the corrosion rate.

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Section: Introductionmentioning

confidence: 99%

Mechanical Behavior and In Vitro Corrosion of Cubic Scaffolds of Pure Magnesium Processed by Severe Plastic Deformation

Silva

Câmara

Hohenwarter

et al. 2021

Metals

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“…Dong et al recently developed a 3D cubic interconnected porous Mg-xZn-0.3Ca scaffold through a negative salt pattern molding technique. 51 The Mg alloy scaffold exhibited a porosity of 73.4 ± 2.5% having a main pore and an interconnected pore diameter of 400−500 μm and 50−150 μm, respectively. The porous Mg-3Zn-0.3Ca alloy exhibited a good combination of compressive strength (5.2 ± 0.3 MPa) and Young's modulus (0.39 ± 0.05 GPa), which are very similar to natural cancellous bone.…”

Section: Scaffolds Prepared Through Powder Metallurgymentioning

confidence: 98%

Recent Developments in Engineered Magnesium Scaffolds for Bone Tissue Engineering

Dutta

Roy

2023

ACS Biomater. Sci. Eng.

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Significant attention has been drawn in recent years to develop porous scaffolds for tissue engineering. In general, porous scaffolds are used for non-load bearing applications. However, various metallic scaffolds have been investigated extensively for hard tissue repair due to their favorable mechanical and biological properties. Stainless steel (316L) and titanium (Ti) alloys are the most commonly used material for metallic scaffolds. Although stainless steel and Ti alloys are employed as scaffold materials, it might result in complications such as stress shielding, local irritation, interference with radiography, etc. related to the permanent implants. To address the above-mentioned complications, degradable metallic scaffolds have emerged as a next generation material. Among the all metallic degradable scaffold materials, magnesium (Mg) based material has gained significant attention owing to its advantageous mechanical properties and excellent biocompatibility in a physiological environment. Therefore, Mg based materials can be projected as load bearing degradable scaffolds, which can provide structural support toward the defected hard tissue during the healing period. Moreover, advanced manufacturing techniques such as solvent cast 3D printing, negative salt pattern molding, laser perforation, and surface modifications can make Mg based scaffolds promising for hard tissue repair. In this article, we focus on the advanced fabrication techniques which can tune the porosity of the degradable Mg based scaffold favorably and improve its biocompatibility.

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“…In addition, the structure of the scaffolds utilized for tissue engineering, such as porosity, is also of great concern. Several researchers have focused on the pore-forming ability of scaffolds and internal pore structure of scaffolds [ 10 , 11 , 12 ]. However, scaffolds present relatively simple shapes, such as cylinder, cube, and thin film shapes.…”

Section: Introductionmentioning

confidence: 99%

Micro/Nanoarchitectonics of 3D Printed Scaffolds with Excellent Biocompatibility Prepared Using Femtosecond Laser Two-Photon Polymerization for Tissue Engineering Applications

et al. 2022

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The fabrication of high-precision scaffolds with excellent biocompatibility for tissue engineering has become a research hotspot. Two-photon polymerization (TPP) can break the optical diffraction limit and is used to fabricate high-resolution three-dimensional (3D) microstructures. In this study, the biological properties, and machinability of photosensitive gelatin methacrylate (GelMA) hydrogel solutions are investigated, and the biocompatibility of 3D scaffolds using a photosensitive GelMA hydrogel solution fabricated by TPP is also evaluated. The biological properties of photosensitive GelMA hydrogel solutions are evaluated by analyzing their cytotoxicity, swelling ratio, and degradation ratio. The experimental results indicate that: (1) photosensitive GelMA hydrogel solutions with remarkable biological properties and processability are suitable for cell attachment. (2) a micro/nano 3D printed scaffold with good biocompatibility is fabricated using a laser scanning speed of 150 μm/s, laser power of 7.8 mW, layer distance of 150 nm and a photosensitive GelMA hydrogel solution with a concentration of 12% (w/v). Micro/nano additive manufacturing will have broad application prospects in the tissue engineering field.

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3D-cubic interconnected porous Mg-based scaffolds for bone repair

Cited by 46 publications

References 48 publications

Mechanical Behavior and In Vitro Corrosion of Cubic Scaffolds of Pure Magnesium Processed by Severe Plastic Deformation

Mechanical Behavior and In Vitro Corrosion of Cubic Scaffolds of Pure Magnesium Processed by Severe Plastic Deformation

Recent Developments in Engineered Magnesium Scaffolds for Bone Tissue Engineering

Micro/Nanoarchitectonics of 3D Printed Scaffolds with Excellent Biocompatibility Prepared Using Femtosecond Laser Two-Photon Polymerization for Tissue Engineering Applications

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