3D culture of mesenchymal stem cells from the yolk sac to generate intestinal organoid

Motta, Lina Castelo Branco; Pereira, Vitória Mattos; Pinto, Paulo Sérgio de Arruda; Mançanares, Celina Almeida Furlanetto; Pieri, Naira Caroline Godoy; Oliveira, Vanessa Cristina de; Neto, Paulo Fantinato; Ambrósio, Carlos Eduardo

doi:10.1016/j.theriogenology.2023.06.003

Cited by 1 publication

(1 citation statement)

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“… Multipotent differentiation and functions of mesenchymal stem cells (MSCs) derived from various tissues. MSCs can be isolated from multiple biological tissues, including adult bone marrow, adipose tissue and neonatal tissues, such as the umbilical cord and the placenta, and can differentiate into osteocytes, chondrocytes, adipocytes and other mesodermal lineages ( 21 ) and exhibit endodermic (such as hepatocytes, muscle cells, gut epithelial cells, and cholangiocytes) ( 20 , 22 – 28 ) and ectodermic (epithelial cells and neuronal cells) ( 29 – 33 ) differentiation potential. MSCs also have strong self-renewal properties.…”

Section: Definition and Source Of Mesenchymal Stem Cellsmentioning

confidence: 99%

Isolation, culture, and delivery considerations for the use of mesenchymal stem cells in potential therapies for acute liver failure

Yang,

Chen,

2023

Front. Immunol.

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Acute liver failure (ALF) is a high-mortality syndrome for which liver transplantation is considered the only effective treatment option. A shortage of donor organs, high costs and surgical complications associated with immune rejection constrain the therapeutic effects of liver transplantation. Recently, mesenchymal stem cell (MSC) therapy was recognized as an alternative strategy for liver transplantation. Bone marrow mesenchymal stem cells (BMSCs) have been used in clinical trials of several liver diseases due to their ease of acquisition, strong proliferation ability, multipotent differentiation, homing to the lesion site, low immunogenicity and anti-inflammatory and antifibrotic effects. In this review, we comprehensively summarized the harvest and culture expansion strategies for BMSCs, the development of animal models of ALF of different aetiologies, the critical mechanisms of BMSC therapy for ALF and the challenge of clinical application.

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